中国医科大学学报2017，Vol.46Issue(9)：779-782,786,5.DOI:10.12007/j.issn.0258-4646.2017.09.003
MTHFRC677T、MTHFRA1298C和MTRRA66G基因的多态性与急性髓系白血病的相关性分析
Relationship of the MTHFRC677T , MTHFRA1298C , and MTRRA66G Gene Polymorphisms with Acute Myelocytic Leukemia
摘要
Abstract
Objective To investigate the relationship of the MTHFRC677T,MTHFRA1298C,and MTRRA66G gene polymorphisms with acute myelocytic leukemia (AML).Methods Mononuclear cells were collected from 63 patients diagnosed with AML,and 60 healthy,non-AML control-group patients.DNA extracted from each sample was screened for the MTHFRC677T,MTHFRA1298C,and MTRRA66G polymorphisms.Results No significant difference was observed in the distribution of the MTHFRC677T,MTHFRA1298C,and/or MTRRA66G polymorphisms between the two patient groups.In contrast,the MTRR G allele was observed to occur 1.935 times more frequently than the MTRR an allele (x2 =4.708,P ＜ 0.05,95％ CI:1.061-3.530).No significant difference was observed in the distribution of a combination of the three gene polymorphisms (MTHFRC677T,MTHFRA1298C,and MTRRA66G)between the AML and the control group.Conclusion The results of the present study suggest that the MTHFRC677T,MTHFRA1298C,and MTRRA66G polymorphisms are not associated with AML.关键词
MTHFRC677T/MTHFRA1298C/MTRRA66G/基因多态性/叶酸/急性髓系白血病Key words
MTHFRC677T/MTHFRA1298C/MTRRA66G/gene polymorphism/folic acid/acute myelocytic leukemia分类
医药卫生引用本文复制引用
王琪,符爽,傅煜,张继红..MTHFRC677T、MTHFRA1298C和MTRRA66G基因的多态性与急性髓系白血病的相关性分析[J].中国医科大学学报,2017,46(9):779-782,786,5.基金项目
国家自然科学基金(81300420) （81300420）
