中国药理学通报2017，Vol.33Issue(12)：1633-1637,5.DOI:10.3969/j.issn.1001-1978.2017.12.002
姜黄素逆转非小细胞肺癌分子靶向药物耐药的研究进展
Research progress of reversion molecular targeted drug resistance in non-small cell lung cancer by curcumin
摘要
Abstract
In recent years,molecular biology has rapidly devel-oped,and molecular targeted therapy of non-small cell lung cancer has become a hot spot for the research. Although the tar-geted therapy has a big advantage compared with traditional chemotherapy,it is inevitable to encounter drug resistance in targeted therapy. Therefore,drug resistance has become the sig-nificant obstacle of targeted drugs for the treatment of non-small-cell lung cancer(NSCLC). Curcumin is the main extract of tu-meric rhizome,which harbours a wide range of antitumor activi-ties,and several studies have identified that curcumin exhibits reversion drug resistance against a variety of cancer cells. How-ever,there are few studies on curcumin reversion molecular tar-geted drug resistance. This review summarizes the recent pro-gress in resistance mechanism of targeted drug and the reversion resistance of curcumin.关键词
分子靶向药物/药物耐药/非小细胞肺癌/姜黄素/耐药机制/逆转耐药Key words
molecular targeted drug/drug resistance/non-small-cell lung cancer(NSCLC)/curcumin/resistance mecha-nism/reversion resistance分类
医药卫生引用本文复制引用
于梦迪,王明霞,王海东..姜黄素逆转非小细胞肺癌分子靶向药物耐药的研究进展[J].中国药理学通报,2017,33(12):1633-1637,5.基金项目
河北省人力资源和社会保障厅留学回国人员科技活动择优资助项目( No 20100313) （ No 20100313）
河北省中医药管理局科研计划项目(No 2013161) （No 2013161）
