中国药理学通报2017，Vol.33Issue(12)：1638-1641,4.DOI:10.3969/j.issn.1001-1978.2017.12.003
中药活性成分干预肝纤维化分子信号通路的研究进展
Study of active ingredients of Chinese medicine interfering with molecular signaling pathway of liver fibrosis
摘要
Abstract
The occurrence and progression of hepatic fibrosis are regulated by multicytokines and multiple molecular signal trans-duction pathways in cells. Currently,the molecular signaling pathway is the target for drugs to treat diseases. The study of the active ingredients of Chinese medicine to interfere with the sig-naling pathways of liver fibrosis is a hot topic. In the past ten years,it has been reported that hydroxysafflor yellow A,total flavonoids from litchi seed,ursolic acid,curcumin can interfere the signaling pathway of p38MAPK,TGF-β/ Smad,Wnt,Ras/ERK and Hedgehog liver fibrosis. The research on the active in-gredients of Chinese traditional medicine,which is targeted at signaling pathways,is expected to open new areas for Chinese and western medicine in the treatment of liver fibrosis.关键词
肝纤维化/p38MAPK/TGF-β/Smad/Ras/ERK/Hedgehog/中药活性成分Key words
hepatic fibrosis/p38MAPK/TGF-β/ Smad/Ras/ERK/Hedgehog/Hedgehog/active ingredient of TCM分类
医药卫生引用本文复制引用
禤传凤,罗伟生,陈国忠,彭卓嵛,康毅,黄瑞,张扬武..中药活性成分干预肝纤维化分子信号通路的研究进展[J].中国药理学通报,2017,33(12):1638-1641,4.基金项目
国家自然科学基金资助项目(No 8136053,81660779) （No 8136053,81660779）
