中国药理学通报2017，Vol.33Issue(12)：1641-1645,5.DOI:10.3969/j.issn.1001-1978.2017.12.004
长链非编码RNA在肿瘤耐药中的作用
Role of long non-coding RNA in drug resistance of tumor
摘要
Abstract
Long non-coding RNA(lncRNA)is a class of RNAs with a number of nucleotides greater than 200,no specific open reading frame and no protein coding. LncRNA could have a sig-nificant influence on the regulation of gene expression during cell growth,and also play a potential role in the development,pro-gression and resistance of tumors. Consequently,it becomes a new tumor research hot spot after miRNA. Many studies have shown that aberrant expression of lncRNA may lead to anti-tumor drug resistance. Furthermore,this resistance is not only derived from individual differences in patients,but also from genetic and epigenetic differences in the tumor. In this paper,we summarize the recent advances in lncRNAs associated with drug resistance that may help overcome drug resistance,so as to improve and develop new therapeutic strategies.关键词
长链非编码RNA/肿瘤/耐药性/分子机制/基因调控/靶点Key words
long non-coding RNA/tumor/drug resistance/mo-lecular mechanism/gene regulation/target分类
医药卫生引用本文复制引用
高梦如,魏小丽,顾康生..长链非编码RNA在肿瘤耐药中的作用[J].中国药理学通报,2017,33(12):1641-1645,5.基金项目
安徽省对外科技合作计划项目(No 1604b0602027) （No 1604b0602027）
