中国药理学通报2017，Vol.33Issue(12)：1645-1650,6.DOI:10.3969/j.issn.1001-1978.2017.12.005
Ets转录因子的生理作用研究进展
Physiological functions of Ets family of transcription factors
摘要
Abstract
Ets is one largest family of the transcription factors with complex structure and function of all family members. They play an important role in the regulation of many physiological and pathological processes through regulating embryonic develop-ment,cell growth,differentiation,cell apoptosis and interac-tions of cells under the regulation of MAP kinases(ERK,p38 and JNK),Ca2 + relevant signaling pathways and TGF-β path-ways. Notably,many Ets members involve in tumor genesis,in-vasion and metastasis,and these members may be markers of anticipating tumor genesis,development and prognosis. Here the physiological role of Ets family members and its relationship with human diseases are summarized,aiming to provide a theoretical basis for the study of the role of Ets family in human diseases.关键词
Ets转录因子/胚胎发育/生长/分化/凋亡/肿瘤/生理作用Key words
Ets transcription factors/embryonic development/growth/differentiation/apoptosis/tumor/physiological function分类
医药卫生引用本文复制引用
曾红,杨洋,安输,郭晓汐,郝倩,徐天瑞,刘莹..Ets转录因子的生理作用研究进展[J].中国药理学通报,2017,33(12):1645-1650,6.基金项目
国家自然科学基金资助项目(No 81560455,81460417, 81460253,U1302225) （No 81560455,81460417, 81460253,U1302225）
云南省高端科技人才基金资助项目(No 2012HA008) （No 2012HA008）
