中国药理学通报2017，Vol.33Issue(12)：1651-1655,5.DOI:10.3969/j.issn.1001-1978.2017.12.006
肝细胞程序性坏死在肝损伤中的研究进展
Research progress of hepatocyte necroptosis in liver injuries
摘要
Abstract
Various pathological factors can result in the death of hepatocytes during liver injury. Persistent hepatocyte death initi-ates and aggravates chronic inflammation and fibrosis,ultimately leading to liver cirrhosis and hepatocellular carcinoma. Thus, limiting hepatocyte death is an effective strategy for improving liver injury. Necroptosis is a newly characterized form of cell death,which is highly regulated by signaling pathways and has typical morphological features of necrosis. Increasing evidence indicates that necroptosis plays a key role in drug-induced or im-munological acute liver injuries,and in chronic liver injuries in-cluding alcoholic fatty liver,nonalcoholic fatty liver and liver fi-brosis. This article reviews the recent advances on the hepato-cyte necroptosis in liver injury,providing novel insights into the pathogenesis of liver disease and related therapeutic reagents.关键词
程序性坏死/肝细胞/肝损伤/酒精性脂肪肝/非酒精性脂肪肝/肝纤维化Key words
necroptosis/hepatocyte/liver injury/alcoholic fatty liver/nonalcoholic fatty liver/liver fibrosis分类
医药卫生引用本文复制引用
贾岩,金欢欢,李蒙蒙,王玲,王飞虾,张晨曦,张峰,郑仕中..肝细胞程序性坏死在肝损伤中的研究进展[J].中国药理学通报,2017,33(12):1651-1655,5.基金项目
国家自然科学基金项目 (No 31571455,31401210, 31600653,81600483,81270514) （No 31571455,31401210, 31600653,81600483,81270514）
江苏省自然科学基金项目(BK20140955) （BK20140955）
江苏省中药药效与安全性评价重点实验室开放课题(No JKLPSE201502) （No JKLPSE201502）
江苏高校优势学科建设工程资助项目(PAPD) （PAPD）
