中国药理学通报2017，Vol.33Issue(12)：1698-1702,5.DOI:10.3969/j.issn.1001-1978.2017.12.014
西洋参茎叶皂苷对糖尿病大鼠氧化损伤和血管内皮功能的影响
Influence of Panax quinquefolium saponins on oxidative damage and function of vascular endothelium in diabetic rats
摘要
Abstract
Aim To investigate the protective effect of Panax quinquefolium saponins (PQS ) on oxidative damage and function of vascular endothelium. Meth-ods After 3 days of adaptive feeding of Wistar male rats,56 rats were randomly selected as the control group,while others were induced by streptozotocin (STZ,30 mg·kg - 1 ). The diabetic rats were random-ly divided into three groups:the model group,PQS group(100 mg · kg - 1 )and Vitamin E group (100μmol·kg - 1 ). The normal group was injected with e-qual amount of citrate buffer. PQS and Vitamin E groups of diabetic rats were administered orally once a day. After 4,8,16 weeks of administration,the con-centration of blood glucose and LPO,SOD of serum, heart and kidney were measured,and the tension of the aortic vascular ring was determined. Results Compared with model group,with prolongation of med-ication,the concentration of glucose and the LPO of serum,heart and kidney in the PQS group significantly decreased(P < 0. 05,P < 0. 01),then the results of the aortic vascular ring tension showed that acetylcho-line induced vasodilatation and maximum diastolic per-cent were obviously elevated in PQS group(P < 0. 05, P < 0. 01). Conclusion PQS could elevate the an-tioxidant function in diabetic rats,thus improving the endothelium-dependent vasodilation function and inter-fering with the occurrence and development of diabetic vascular complications关键词
西洋参茎叶皂苷/糖尿病大鼠/内皮损伤/抗氧化/LPO/SOD/主动脉血管环Key words
Panax quinquefolium saponins/diabetic rats/endothelial injury/antioxidant/LPO/SOD/aor-tic vascular rings分类
医药卫生引用本文复制引用
李吉萍,袁野,张文友..西洋参茎叶皂苷对糖尿病大鼠氧化损伤和血管内皮功能的影响[J].中国药理学通报,2017,33(12):1698-1702,5.基金项目
扬州大学校基金项目(No K0111232) （No K0111232）
