中国药理学通报2017，Vol.33Issue(12)：1713-1717,5.DOI:10.3969/j.issn.1001-1978.2017.12.017
阳离子阿奇霉素微类脂体体内外相关性
In vivo and in vitro correlation of azithromycin cationic micron niosomes
摘要
Abstract
Aim To evaluate the correlation between in vitro release and in vivo absorption of azithromycin cat-ionic micron niosomes (ACMNS)by Wagner-Nelson method and deconvolution method. Methods The in vitro release behavior of ACMNS was studied by dy-namic membrane dialysis. After a single dose of intra-gastric administration with ACMNS and AM in rats,the AM concentrations in plasma were determined by high performance liquid chromatography(HPLC). Wagner-Nelson and deconvolution method were used to reveal the in vitro / in vivo correlation. Results X used as cu-mulative in vitro release and Fa as the absorption per-centage,the regression equation was established:F a =3. 0524X - 5. 7709,r = 0. 8976,and X used as cumu-lative in vitro release and R as input function,the re-gression equation was established:R = 2. 3413X -58. 687,r = 0. 5217. r < r( 2,0. 05) = 0. 9500 (P <0. 05). Conclusion There is no correlation between in vitro release and in vivo absorption of ACMNS.关键词
阿奇霉素/微类脂体/药代动力学/Wagner-Nelson法/反卷积分法/体内外相关性Key words
azithromycin/micron niosomes/pharma-cokinetics/Wagner-Nelson method/deconvolution method/in vitro and in vivo correlation分类
医药卫生引用本文复制引用
曾梅,钟萌,冯悦,罗见春,张奇娆,张景勍..阳离子阿奇霉素微类脂体体内外相关性[J].中国药理学通报,2017,33(12):1713-1717,5.基金项目
重庆市基础与前沿研究计划重点项目(No cstc2015jcyjBX0027) （No cstc2015jcyjBX0027）
