中国药理学与毒理学杂志2017，Vol.31Issue(7)：766-771,6.DOI:10.3867/j.issn.1000-3002.2017.07.010
α5GABAA受体及其变构调节剂对学习记忆功能作用的研究进展
Progress in α5GABAA receptors and their allosteric modulators in learning-memory
赵自芳 1高腾 1尹毅青1
作者信息
- 1. 中日友好医院手术麻醉科,北京 100029
- 折叠
摘要
Abstract
Alpha 5 subunit-containing γ-aminobutyric acid type A receptors (α5GABAARs), mainly distributed in the hippocampus, are an inhibitory synaptic receptor of the central nervous system.α5GABAARs inhibit the hippocampal neurons by mediating a chloride leak current. A number of studies have demonstrated that alterations in the level of excitability of α5GABAARs impair cognitive function and learning-memory, thus resulting in a series of diseases and symptoms including postoperative cognitive dysfunction, pain, depression, schizophrenia and Down syndrome. Accordingly, allosteric modulators for α5GABAARs show therapeutic or improving effects on the above clinical diseases. This review mainly discusses the physiology of α5GABAARs, impact on cognition and key effects of these allosteric modulators.关键词
α5亚基γ-氨基丁酸A受体/海马/认知/学习记忆/调节剂Key words
Alpha 5 subunit-containingγ-aminobutyric acid type A receptors/hippocampus/cogin-tion/learning-memory/modulators分类
医药卫生引用本文复制引用
赵自芳,高腾,尹毅青..α5GABAA受体及其变构调节剂对学习记忆功能作用的研究进展[J].中国药理学与毒理学杂志,2017,31(7):766-771,6.
