中国药业2017，Vol.26Issue(22)：8-11,4.DOI:10.3969/j.issn.1006-4931.2017.22.003
注射用盐酸丙帕他莫合理调配方案研究
Rational Dispensation of Propacetamol Hydrochloride for Injection
摘要
Abstract
Objective To investigate the rational dispensation method of Propacetamol Hydrochloride for Injection,and to ensure the safe-ty and effectiveness of deployment of the finished product. Methods The propacetamol hydrochloride was diluted by volume ratio of 1:50,which were compatible with 0. 9％ Sodium Chloride Injection,5％ Glucose and Sodium Chloride Injection,10％ Glucose Injection, 5％ Glucose Injection and Invert Sugar Injection,and 0. 9％ Sodium Chloride Injection diluted by the volume ratio of 1:100. The mor-phological characteristics of the mixture were observed,and the pH,insoluble particles and content change of propacetamol hydrochloride were measured. Results 0. 9％ Sodium Chloride Injection was chosen as solvent,in accordance with the volume ratio of 1:50 diluted solution of the drug compatibility and good stability in 2 h. There was little change in the content of propacetamol hydrochloride,and the pH and insoluble particles met the requirements. Conclusion 0. 9％ Sodium Chloride Injection should be used as preferred solvent with dilution volume ratio of 1:50 for Propacetamol Hydrochloride for Injection and it should be used in a short time after configured.关键词
丙帕他莫/合理调配/高效液相色谱法Key words
propacetamol hydrochloride/rational dispensation/HPLC分类
医药卫生引用本文复制引用
许红,李国春,伍伦玲,尹加珍,李欣欣..注射用盐酸丙帕他莫合理调配方案研究[J].中国药业,2017,26(22):8-11,4.基金项目
泸州医学院课题[(2013)22号]. （2013）
