中国药业2017，Vol.26Issue(22)：12-14,3.DOI:10.3969/j.issn.1006-4931.2017.22.004
匹多莫德治疗小儿支原体肺炎的疗效及对
Foxp3基因表达的影响
Clinical Effect of Pidotimod in Treating Mycoplasma Pneumonia and Its Effect on Expression of Foxp3 Gene
潘娜 1崔亚琦 1焦黎旭1
作者信息
- 1. 河南省郑州市妇幼保健院药剂科,河南郑州 450002
- 折叠
摘要
Abstract
Objective To observe the clinical effect of pidotimod for treating mycoplasma pneumonia and its effect on the expression of Foxp3 gene. Methods Totally 112 children patients with mycoplasma pneumonia admitted to our hospital from January to December in 2016 were selected and divided into the control group and the observation group by random number table method,56 cases in each group. The control group was given conventional treatment and azithromycin,on this basis,the observation group was given pidotimod. After 30 d of treatment,the clinical effect between the two groups was compared. Another 50 healthy children volunteers were selected as the normal group,and the expression of Foxp3 gene was monitored by fluorescence quantitative PCR in the three groups. The regulatory T cells were detected by flow cytometry(FCM). Results After 30 d of treatment,the total effective rate of the observation group was 92. 86％,which was significantly higher than 82. 14％ of the control group (P < 0. 05 ). Before treatment ,there was no significant difference in the expression of Foxp3 gene and the proportion of Treg cells between the observation group and the control group (P > 0. 05),but those in the two groups were significantly lower than those in the normal group (P < 0. 05). After treatment,the increase of the expression of Foxp 3 gene and the proportion of Treg cells in the observation group and the control group was significantly higher than before treatment ,and that in the observation group was significantly higher than that in the control group (P < 0. 05). Conclusion Pidomorph for treating children with mycoplasma pneumonia has good effect,it can significantly improve the expression of Foxp3 gene and the proportion of Treg cells and enhance immunity,which is worthy of clinical promotion.关键词
匹多莫德/小儿/支原体肺炎/Foxp3基因/疗效Key words
pomodomide/chidren/mycoplasma pneumonia/Foxp3 gene/curative effect分类
医药卫生引用本文复制引用
潘娜,崔亚琦,焦黎旭..匹多莫德治疗小儿支原体肺炎的疗效及对
Foxp3基因表达的影响[J].中国药业,2017,26(22):12-14,3.
