中国药业2017，Vol.26Issue(22)：24-27,4.DOI:10.3969/j.issn.1006-4931.2017.22.008
盐酸贝那普利片近红外光谱定性分析模型的建立
Establishment of Near-Infrared Spectroscopy Qualitative Model for Benazepril Hydrochloride Tablets
金鹏 1刘艳 1卜媛媛1
作者信息
- 1. 江苏省淮安市食品药品检验所,江苏淮安 223300
- 折叠
摘要
Abstract
Objective To establish a qualitative analysis model for Benazepril Hydrochloride Tablets. Methods Near-infrared diffuse re-flectance spectrophotometry (NIRDRS)was adopted to collect near-infrared spectra (NIRS)of 61 batches of samples from 4 manufac-turers,chemometrics spectral aanalysis software OPUS was adopted to establish the two-layer qualitative model and series confirmed model,and the accuracy and specificity of the model were verified. Results The model had good accuracy and specificity,it can accu-rately identify 21 batches of samples and distinguish 4 structural analogues,counterfeit A enterprise samples and 21 non-structural analogues. Conclusion The model established in this experiment can quickly and accurately identify the authenticity of Benazepril Hydroch1oride Tab1ets,which is suitable for the spot rapid diagnosis of the drug on the drug testing vehicles.关键词
近红外光谱/盐酸贝那普利片/定性分析模型/快速鉴别Key words
near-infrared spectroscopy/Benazepril Hydrochloride Tablets/qualitative analysis model/rapid identification分类
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金鹏,刘艳,卜媛媛..盐酸贝那普利片近红外光谱定性分析模型的建立[J].中国药业,2017,26(22):24-27,4.
