摘要
Abstract
Objective To investigate the clinical effect of compound traditional Chinese medicine(TCM)preparation (Guanxin Ⅴ Mixture) in the treatment of ventricular remodeling after acute myocardial infarction (AMI) and its mechanism. Methods Totally 90 patients with AMI admitted to our hospital from January 2014 to May 2016 were selected and divided into the TCM group and the normal group according to the random number table method,45 cases in each group. The two groups were treated with oral Aspirin Enteric-Coated Tablets,subcutaneous injection of low molecular weight heparin calcium and other basic treatment,on this basis,the TCM group was given Guanxin Ⅴ Mixture. The two groups were treated for 8 weeks. Results After 8 weeks of treatment,the levels of NT-proBNP, hs-CRP,MMP-9,Ang Ⅱand ET-1,LVEDD,LVESD,LVEF,LVESV,LVEDV,LVPWT,IVST of the TCM group were significantly lower than those of the normal group (P < 0. 05),but the level of LVEF was significantly higher than that of the normal group (P < 0. 05). Conclusion Compound TCM preparation (Guanxin Ⅴ Mixture)in the treatment of ventricular remodeling after AMI can improve heart function and inhibit ventricular remodeling by reducing the serum factors related to ventricular remodeling.关键词
中药/冠心Ⅴ号合剂/急性心肌梗死/心室重构/作用机制/临床疗效Key words
traditional Chinese medicine/Guanxin Ⅴ Mixture/acute myocardial infarction/ventricular remodeling/mechanism/clinical effect分类
医药卫生
