中国药业2017，Vol.26Issue(22)：86-88,3.DOI:10.3969/j.issn.1006-4931.2017.22.029
头孢他啶联合阿米卡星对铜绿假单胞菌感染的药学干预分析
Pharmaceutical Intervention of Ceftazidime Combined with Amikacin in Treating of Pseudomonas Aeruginosa Infection
曾菁 1肖瑶 1奉川程 1周理国1
作者信息
- 1. 重庆市綦江区人民医院,重庆 401420
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy and safety of pharmaceutical intervention on Pseudomonas aeruginosa (PA) infection. Methods Totally 84 patients with PA infection admitted to our hospital from August 2015 to May 2017 were selected, whether the intervention was played or not according to whether the initial dosing regimen was optimized or not(with ceftazidime combined with amikacin therapy less than 3 times / day). The observation group (44 cases)had been optimized or accepted the intervention,and the control group (40 cases)was refused intervention. The clinical data and the distribution of the disease before and after treatment were recorded in the two groups. Results The course of treatment,hospitalization time and recovery time of body temperature of the observation group were lower than those of the control group,and the cases of improved patients and bacterial clearance rate were higher than those of the control group (P < 0. 05). After 3 d of treatment,the proportion of WBC and NEUT returned to normal in the two groups was not statistically significant (P > 0. 05). After 7 d of treatment,the proportion of WBC and NEUT returned to normal in the observation group was higher than that in the control group (P < 0. 05). In the treatment,there were 1 case with mild allergic reactions due to the use of cefoperazone sulbactam in the observation group,and 2 cases in the control group,the clinical manifestation was systemic rash,and the symptoms were obviously improved after the drug withdrawal and giving anti-allergy treatment in time. Conclusion The intervention of PA infection can significantly improve the clinical efficacy,and has good safety,which is worthy of clinical promotion.关键词
头孢他啶/阿米卡星/铜绿假单胞菌感染/药学干预/临床疗效Key words
ceftazidime/amikacin/Pseudomonas aeruginosa infection/pharmaceutical intervention/clinical effect分类
医药卫生引用本文复制引用
曾菁,肖瑶,奉川程,周理国..头孢他啶联合阿米卡星对铜绿假单胞菌感染的药学干预分析[J].中国药业,2017,26(22):86-88,3.
