针灸临床杂志2017，Vol.33Issue(9)：57-60,4.
电针对膝关节骨性关节炎大鼠关节液中IL-1β、MMP-13和S100A12蛋白表达的影响
Expression of IL-1β、MMP-13 and S100A12 Protein in Joint Fluids of Knee Osteoarthritis Rats Influenced by Electro-acupuncture
摘要
Abstract
Objective:To observe the effect of electro-acupuncture on IL-1β 、MMP-13 and S100A12 protein expression in joint fluids of knee osteoarthritis rats.Methods:30 SD rats were randomly divided into the blank group,the model group and the electro-acupuncture group.The models were established by injecting 4％ papain.IL-1β 、MMP-13 and S100A12 protein content in joint fluid were tested wtih Elisa method five weeks and seven weeks respectively after the establishment of successful models.Results:The levels of IL-1β,MMP-13,S100A12 protein content in the model group and electro-acupuncture group were significantly higher than those of the blank group at both time points (P ＜ 0.05);but those levels were significantly lower than those of the model group at the same time point (P ＜ 0.05);moreover,those levels of seven weeks after were lower than those of five weeks after,and the difference was statistically significant(P ＜0.05);however,there was no statistical significance between the seven weeks after and five weeks after in the model group(P ＞0.05).Conclusion:Electro-acupuncture may promote the recovery of the structure and function of arthrodial cartilage by down-regulating the expression of IL-1 β,MMP-13 and S100A12 protein,inhibiting the release of inflammatory factor,preventing the degradation of cartilage matrix,regulating the immune response of the organism.关键词
膝关节骨性关节炎/电针/IL-1β/MMP-13/S100A12Key words
Knee osteoarthritis/Electro-acupuncture/IL-1β/MMP-13/S100A12分类
医药卫生引用本文复制引用
李洪涛,刘昊,杨方军,李艳秋,孙晓伟..电针对膝关节骨性关节炎大鼠关节液中IL-1β、MMP-13和S100A12蛋白表达的影响[J].针灸临床杂志,2017,33(9):57-60,4.基金项目
黑龙江省科学基金项目,编号:H2017058 （）
黑龙江省博士后资助项目,编号:LHB-Z12265. （）
