北华大学学报（自然科学版）2017，Vol.18Issue(6)：755-758,4.DOI:10.11713/j.issn.1009-4822.2017.06.012
冠心病患者颈动脉内中膜厚度、血尿酸与斑块不稳定性关系研究
Correlation of Carotid Artery Intima-Media Thickness and Serum Uric Acid with Plaque Stability in Patients with Coronary Heart Disease
摘要
Abstract
Objective To study the correlation of serum uric acid and carotid intimal-medial thickness with plaque stability in coronary heart disease (CHD ). Method 148 Patients with CHD who were proved by coronary arterigraphy were selected as the experimental group,and were divided into three subgroups of single-branch,double-branch and three-branch according to the scope of pathological changes by coronary angiogram. The CHD patients were divided into three subgroups of acute myocardial infarction (AMI ),unstable angina pectoris(UAP )and stable angina pector (SAP )according to the WHO standards. 40 Cases were excluded by coronary arterigraphy as control group. Blood uric acid and carotid artery intima-media thickness of all thepatients were measured by carotid ultrasonography,and the correlation of the both with the plaque instability and the coronary lesion branch number with the severity of coronary stenosis were analyzed. Results The serum uricacid level in the different CHD groups was significantly higher than in the control group (P<0. 05). There are significant differences in the serum uric acid level among the three groups,single-vessel group,double-vessel group and three-ressel group (P<0 . 05 ). The serum uric acid was positively correlated with the IMT and coronary Gensini score(r=0. 506,P<0. 05;r=0. 345,P<0. 05). Conclusion Both uric acid and carotid intimal-medial thickness were positively correlated with coronary plaque instability and coronary lesion severity,indicating that the both should be closely related to the instability of coronary plaque and severity of coronary artery lesions inpatients with coronary heart disease,which may help to assess the severity of coronary artery lesions and predict the occurrence of acute coronary syndrome to improve the ability of early diagnosis of coronary heart disease.关键词
血尿酸/颈动脉内中膜厚度(IMT)/动脉粥样硬化斑块/斑块的不稳定性Key words
uric acid/carotid intimal-medial thickness(IMT)/aeteria coronaria atherosclerotic/plaque instability分类
医药卫生引用本文复制引用
郭华涛,徐丽华,常哲兴..冠心病患者颈动脉内中膜厚度、血尿酸与斑块不稳定性关系研究[J].北华大学学报（自然科学版）,2017,18(6):755-758,4.基金项目
吉林省教育厅科学技术研究项目(2012146) （2012146）
吉林市科技发展计划项目(201233121). （201233121）
