北京大学学报（医学版）2017，Vol.49Issue(5)：783-788,6.DOI:10.3969/j.issn.1671-167X.2017.05.007
儿童血管迷走性晕厥和体位性心动过速综合征共患过敏性疾病的临床特征分析
Co-morbidity of vasovagal syncope and postural tachycardia syndrome with allergic diseases in children
摘要
Abstract
Objective:To explore the clinical characteristics of the co-morbidity of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS) with allergic diseases in children.Methods:A retrospective analysis was launched to summarize the clinical data of children with VVS and POTS.They were divided into allergic group and non-allergic group according to the history of allergic diseases.The participants' clinical characteristics were compared between allergic group and non-allergic group using independent sample t test or rank sum test;composition comparisons were completed by Chi-square test.Bi-variate correlation analysis was used to explore the association between eosinophil percentage/count and symptom scores/frequency of syncope episodes.A P value ＜ 0.05 was defined as statistically significant.Results:Sixty-seven children complaining of orthostatic intolerance (43 patients diagnosed as VVS and 24 cases diagnosed as POTS) were enrolled.Totally 21 cases (31％) had allergic diseases,inclu ding allergic rhinitis,atopic eczema,asthma,as well as food allergy.And allergic rhinitis is the most common co-morbidity.There were no significant differences between the two groups in age,gender ratio,height,body weight and basement blood pressure.Compared with the non-allergic group,the allergic group showed later onset age (year) (11 ± 2 vs.9 ± 3,P ＜ 0.05) of orthostatic intolerance and shorter course of the diseases (month) [8.0 (0.1,0.1) vs.24.0 (0.1,144.0),P＜0.05].The frequency of syncope episodes in the allergic group among VVS children (times per month) [2.50 (0.08,30.00) vs.O.25 (0.03,5.00),P ＜ 0.05] was much higher than that in the non-allergic group.Additionally,the eosinophil percentage (％) [3.50 (0.70,0.59) vs.1.65 (0.30,6.20),P＜0.001] and eosino phil count (×109) [0.18 (0.05,0.71) vs.0.10 (0.02,0.38),P＜0.001] were increased in the allergic group.However,there were no remarkable differences in the results of head-up tilt test in children with VVS or in the maximum change of heart rate during standing test in children with POTS were involved.Conclusion:Allergic diseases are common co-morbidities in children with both VVS and POTS.Allergic rhinitis is the most common co-morbidity.Children with co-morbidity of VVS/POTS and allergic diseases had a later onset of symptoms of orthostatic intolerance,and were more likely to be hospitalized for intensive attacks of symptoms during a short period when compared with those without allergic diseases.Children diagnosed as VVS combined with allergic diseases had more frequent episodes of syncope.关键词
晕厥,血管迷走性/体位性心动过速综合征/直立不耐受/过敏Key words
Syncope, vasovagal/Postural orthostatic tachycardia syndrome/Orthostatic intolerance/Allergy分类
医药卫生引用本文复制引用
廖莹,张清友,李红霞,王瑜丽,刘平,杜军保..儿童血管迷走性晕厥和体位性心动过速综合征共患过敏性疾病的临床特征分析[J].北京大学学报（医学版）,2017,49(5):783-788,6.基金项目
北京市科技计划课题(Z171100001017253)资助 Supported by Beijing Municipal Science and Technology Major Project (Z171100001017253) （Z171100001017253）
