长春中医药大学学报2017，Vol.33Issue(6)：871-874,4.DOI:10.13463/j.cnki.cczyy.2017.06.004
苦瓜总皂苷对阿霉素肾病大鼠P-GSK-3β 表达的影响
Effects of momordicosides to P-GSK-3β in rats with adriamycin nephropathy
摘要
Abstract
Objective To study the effect of momordicosides to P-GSK-3β in rats with adriamycin nephropathy. Methods 50 SD rats were randomly divided into blank group, model group, low, middle and high momordicosides dose treatment group, after built model, renal pathology, renal function and P-GSK-3β were detected. Results Compared with the blank group, the quantitative of 12 h protein, BUN, Scr, TG and CHO in the model group were significantly higher (P < 0.05), above mentioned indicators were lowed in momordicosides group compared with the model group (P < 0.05). Compared with the blank group, the levels of TP, ALB, Bax, and Bcl-2 were significantly low (P < 0.05), compared with the model group, they were higher in momordicosides treatment group (P < 0.05). Histopathological can be seen, there is no abnormality in the blank group, the epithelial cells were obviously denatured in the model group, after using momordicosides, it was significantly improved. Compared with the blank group, the expression of P-GSK-3β was significantly lower in the model group than in the model group (P < 0.05), the momordicosides was significantly improved compared with the model group (P < 0.05). Conclusion Momordicosides can improve the renal function of rats with adriamycin nephropathy, which may be related with it can decrease the expression of P-GSK-3β.关键词
苦瓜总皂苷/阿霉素肾病/磷酸化糖原合成酶激酶-3βKey words
momordicosides/adriamycin nephropathy/P-GSK-3β分类
医药卫生引用本文复制引用
王玲,吴秋枫..苦瓜总皂苷对阿霉素肾病大鼠P-GSK-3β 表达的影响[J].长春中医药大学学报,2017,33(6):871-874,4.基金项目
湖北省科技厅创新项目(2015CFC187). （2015CFC187）
