长春中医药大学学报2017，Vol.33Issue(6)：874-876,3.DOI:10.13463/j.cnki.cczyy.2017.06.005
桦褐孔菌对大鼠血管性痴呆的保护作用机制
Study on protective mechanism of Inonotus obliquus against Vascular dementia in rats
摘要
Abstract
Objective To observe the protective effect mechanisms of Inonotus obliquus on Vascular dementia (VD) rats. Methods Wistar rats were selected, used repeatedly occlusion of bilateral common carotid arteries and reperfusion, combined with intraperitoneal injection of sodium nitroprusside depressor preparation of VD animal model, randomly divided into control group, model group, IO group (0.5, 1.0, 2.0 g/kg), and intragastric administration for 8 weeks. The changes of free radical and related enzymes and cholinergic system in the brain tissue of rats were detected. Results Free radical and enzyme assay showed that compared with the model group, SOD and CAT activity of brain tissue in rats of Inonotus obliquus groups increased and MDA content decreased (P < 0.05), Na+-K+-ATP and the activity of the enzyme GSH-PX activity had no obvious change, inonotusobliquus large dose group (2.0 g/kg) Ca2+-Mg2+-ATP enzyme activity in rat' s brain increased significantly (P < 0.05). The detection of cholinergic system and related enzymes showed that there were no significant changes in the content of acetylcholine and cholinesterase in the brain tissue of the rats in each dose group compared to the model group. Conclusion The protective mechanism of obliquus obliquus against VD rats may be related to enhancing the activity of anti free radical related enzymes, increasing the antioxidant capacity of the body, and alleviating the damage of free radical in brain tissue; its mechanism maybe irrelevant to choline system.关键词
桦褐孔菌/血管性痴呆/大鼠/自由基/胆碱能系统Key words
Inonotus obliquus/VD/rat/free radical-related/cholinergic system-related分类
医药卫生引用本文复制引用
宫睿,谢湘林,杜冰,武毅,刘宏雁..桦褐孔菌对大鼠血管性痴呆的保护作用机制[J].长春中医药大学学报,2017,33(6):874-876,3.基金项目
吉林省科学技术厅科技引导计划项目(201205020). （201205020）
