长春中医药大学学报2017，Vol.33Issue(6)：890-892,3.DOI:10.13463/j.cnki.cczyy.2017.06.010
复方胡黄连对D-半乳糖致急性肝损伤的保护作用及机制
Protective effect and mechanism of compound Figwortflower Picrorhiza Rhizome on acute liver injury induced by D-galactose
摘要
Abstract
Objective To explore the protective effect and mechanism of compound Figwortflower Picrorhiza Rhizome on the acute liver injury induced by D-galactose. Methods Sixty Kunming rats were randomly divided into blank control group, model control group, positive control group (545 mg/kg) of liver with jiaxin tablets, compound Figwortflower Picrorhiza Rhizome high dose group (34 mg/kg), compound Figwortflower Picrorhiza Rhizome medium dose group (17 mg/kg), compound Figwortflower Picrorhiza Rhizome low dose group (8.5 mg/kg). There were 10 rats in each group, consecutive lavage for seven days. Give the tablets at 6 a.m. on the seventh day and mold in 2 hours. In addition to the blank group, the other groups were injected with 0.1% D-galactose, 0.3 mL/ 10g, and the blood was taken after 24 hours, with automatic biochemical analyzer determination of ALT, AST, remove the liver tissue, according to the requirement of the kit for determining the content of SOD, MDA. Results Compared with blank group, the serum levels of ALT and AST in model group were significantly increased (P < 0.01), SOD in the liver tissue decreased significantly, the MDA content increased significantly. Compound Figwortflower Picrorhiza Rhizome each dosage group compared with model group, can significantly reduce serum ALT and AST levels (P< 0.01), increase SOD activity in liver tissue, reduce MDA content (P < 0.01), pathological structure to improve its damage. Conclusion The treatment of acute liver injury induced by compound Figwortflower Picrorhiza Rhizome to rats with D-galactose, which can significantly reduce the serum ALT and AST activity, can significantly increase SOD content in liver tissues and decrease MDA content.关键词
复方胡黄连/急性肝损伤/保护作用Key words
compound Figwortflower Picrorhiza Rhizome/acute liver injury/protection mechanism分类
医药卫生引用本文复制引用
王晓源,韩翠翠,肖洪彬..复方胡黄连对D-半乳糖致急性肝损伤的保护作用及机制[J].长春中医药大学学报,2017,33(6):890-892,3.基金项目
黑龙江省教育厅科学技术研究项目(12541737). （12541737）
