长春中医药大学学报2017，Vol.33Issue(6)：893-896,4.DOI:10.13463/j.cnki.cczyy.2017.06.011
电针对2型糖尿病大鼠右心房自主神经损害的调节作用
Regulating effect of electroacupuncture in the right atrium autonomic nerve damage of type 2 diabetic rats
摘要
Abstract
Objective To investigate the regulating effect of electroacupuncture on the autonomic neurotrophic factor in the right atrium of type 2 diabetic rats, and to provide reference for electroacupuncture clinical optimization. Methods Sixty SD rats were randomly divided into four groups: blank control group, DM model group, electroacupuncture group 1 and electroacupuncture group 2. Except the blank control group, the other three groups were fed with high fat and high glucose for 4 weeks. The experimental diabetic rats were injected intraperitoneally with STZ for 2 days at 25 mg.kg-1. After 2 weeks of modeling, the blank control group and DM model group were not treated; electroacupuncture 1 group: select Neiguan (PC6), Quchi (LI11), Zusanli (ST36), Sanyinjiao (SP6);electroacupuncture 2 group: select Feishu (BL13), Xinshu (BL15), Yishu (EX-B3), Pishu (BL20), Shenshu(BL23). Once a day, six days for a course of treatment, continuous treatment for four courses, one-day rest between the courses. TH, ChAT, NGF, GAP-43, and ciliary, Nerve growth factor (CNTF) in the right atrium of rats were assessed with ELISA. Results ChAT of DM group decreased significantly (P <0.05), NGF was increased significantly (P <0.05), GAP-43 and CNTF were significantly decreased (P < 0.05) in the DM model group compared with the control group;the ChAT of the two electroacupuncture groups increased significantly (P <0.05) NGF decreased significantly (P <0.05), GAP-43 and CNTF were significantly increased (P < 0.05) compared with DM model, electroacupuncture group 1 was superior to electroacupuncture 2 group. Conclusion Electroacupuncturing on limbs has a good effect on FPG of DM model rats, electroacupuncture can regulate the right ventricular autonomic neurotrophic factor balance, reduce the degree of autonomic nerve fiber damage and group of limbs acupoints better than that of group of back transport points.关键词
2型糖尿病/心脏自主神经病变/电针疗法Key words
type 2 diabetes/cardiac autonomic neuropathy/electroacupuncture分类
医药卫生引用本文复制引用
祝恩智,李南溪,张宇,高婉宁,王洪峰,逄紫千..电针对2型糖尿病大鼠右心房自主神经损害的调节作用[J].长春中医药大学学报,2017,33(6):893-896,4.基金项目
2017 年国家自然科学基金资助项目(81674051) （81674051）
2016 年吉林省教育厅 " 十三五 " 科研课题(01080864) （01080864）
2017 年大学生创新创业训练计划 ( 国家级 )(201710199002) （ 国家级 ）
2016 年吉林省高等教育学会高教科研课题(JGJX2016C17). （JGJX2016C17）
