重庆医学2017，Vol.46Issue(32)：4481-4483,3.DOI:10.3969/j.issn.1671-8348.2017.32.005
枸杞总黄酮提取物对2型糖尿病大鼠血管内皮细胞的保护作用
Protective effect of total flavonoids of lycium barbarum on vascular endothelial cells in type 2 diabetic rats
摘要
Abstract
Objective To study the protective effect of total flavonoids of lycium barbarum(TFLB) on vascular endothelial cells in streptozotocin(STZ)-induced diabetic mellitus(DM) rats injury model.Methods The injury model of DM rats was induced by STZ,and the rats were divided into normal control group,DM model group and TFLB interventiongroup(60,90 and 120 mg/mL).Rats in the normal control group and the DM model group were given the same amount of intragastric administration of normal saline every day.The rats in the intervention group were treated with TFLB at different concentrations for 4 weeks.After filling the stomach for 4 weeks,the blood samples were taken from the chest cavity,and the changes of serum vWF,sTM and sEPCR were measured by ELISA.The tissue of the thoracic aorta was removed and stained by HE,and the protective effect of TFLB on the vascular endothelium in DM rats was observed.Results Compared with DM model group,the levels of vascular endothelial function related factors vWF,sTM and sEPCR were down-regulated in the TFLB intervention group,and the difference was statistically significant(P＜0.05,P＜0.01).In the TFLB intervention group,with the increase of TFLB dose,the intima thickening degree of the rats was significantly reduced;the formation of mountain-like protrusions was gradually decreased;the outer membrane showed no significant damage;the vascular morphology arrangement tended to be regular.Conclusion TFLB can improve the hyperglycemiacaused damage of vascular endothelial cells,regulate the content of vascular injury related factors,delay the progression of DM complications,and protect the cardiovascular system.关键词
枸杞总黄酮/糖尿病,2型/血管内皮细胞Key words
total flavonoids from lycium barbarum/diabetes,type 2/vascular endothelial cell分类
医药卫生引用本文复制引用
王伟,尚佳,楚元奎..枸杞总黄酮提取物对2型糖尿病大鼠血管内皮细胞的保护作用[J].重庆医学,2017,46(32):4481-4483,3.基金项目
宁夏自然科学基金资助项目(NZ11116) （NZ11116）
氯化锂对小鼠糖尿病动脉粥样硬化防治作用的初步研究(XM2011008). （XM2011008）
