重庆医学2017，Vol.46Issue(32)：4488-4491,4.DOI:10.3969/j.issn.1671-8348.2017.32.007
通络愈足工号方治疗糖尿病足患者的临床疗效观察
Clinical observation on Tongluoyuzufang Ⅰ for patients with diabetic foot
摘要
Abstract
Objective To observe the clinical efficacy and its mechanism of Tongluoyuzufang Ⅰ in patients with diabetic foot (DF).Methods A total of 60 cases with DF was randomly divided into experimental group and control group,30 cases in each group.All patients were given insulin and/or hypoglycemic drugs and other Western medicine comprehensive treatment to control blood sugar steadily.The control group received methylcobalamin treatment,and the experimental group received Tongluoyuzufang Ⅰ therapy treatment based on the methylcobalamin treatment.Both groups were treated for 4 weeks for a course of treatment.The clinical efficacy,ankle-brachial index,nerve conduction velocity,hemorheology,blood lipid,serum cytokines and adverse reactions before and after treatment were compared after 3 courses of treatment.Results After treatment,the total effective rate was 90.0 ％ in the observation group,higher than that in the control group(x2 =5.963,P＜0.05).After treatment,the ankle-brachial index,nerve conduction velocity,hemorheology and blood lipid level in both groups were significantly improved(P＜0.05).After treatment,serum levels of tumor necrosis factor-α(TNF-α) and vascular endothelial growth factor(VEGF) in both groups were significantly decreased,while the levels of anti-thrombin Ⅲ (AT-Ⅲ) has increased(P＜0.05).The improvement of the indexes in the observation group was better than that in the control group(P＜0.05).There were no serious adverse events during treatment.Conclusion Tongluoyuzufang Ⅰ can significantly improve limb ischemia and nerve conduction function in patient with DF.关键词
通络愈足Ⅰ号方/糖尿病足/肿瘤坏死因子-α/血管内皮生长因子/抗凝血酶ⅢKey words
Tongluoyuzufang Ⅰ/diabetic foot/tumor necrosis factor-α/vascular endothelial growth factor/anti-thrombin-Ⅲ分类
医药卫生引用本文复制引用
刘祥秀,王安宇,李波,陈希..通络愈足工号方治疗糖尿病足患者的临床疗效观察[J].重庆医学,2017,46(32):4488-4491,4.基金项目
国家自然科学基金资助项目(81260600) （81260600）
贵州省国际科技合作计划项目[黔科合作G字(2011)7021号] （2011）
贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY2013-28). （QZYY2013-28）
