重庆医学2017，Vol.46Issue(32)：4505-4507,4510,4.DOI:10.3969/j.issn.1671-8348.2017.32.011
维生素D3的补充对儿童哮喘控制的随机对照研究
A randomized controlled study of vitamin D3 supplementation on childhood asthma control
摘要
Abstract
Objective To explore the effect of vitamin D3 supplementation on childhood asthma control for the purpose of providing a scientific basis for preventing the recurrence of childhood asthma.Methods A total of 92 children with asthma enrolled from January 2015 to December 2015 was divided into vitamin D group and placebo group by adopting double-blind randomized controlled design principles.Two groups were given a dose of 800 IU of vitamin D3 and placebo respectively,1 tablet per day for 2 months of treatment.The levels of asthma control and serum 25-hydroxy vitamin D3 and lung function index were examined at baseline,2 months and 6 months.Results A total of 83 patients completed the entire follow-up,including 43 patients in the vitamin D group and 40 patients in the placebo group.After 2 months,the level of asthma control in the vitamin D group was significantly higher than that in the placebo group(P=0.015) and the level of serum 25-hydroxy vitamin D3 was also higher in the vitamin D group than in the placebo group(P=0.042).There was no significant difference of pulmonary function index between the two groups(P＞0.05).After 6 months,the level of asthma control in the vitamin D group was still higher than that in the placebo group with no significant difference(P=0.094).There was no significant difference in the level of serum 25-hydroxy vitamin D3 between the two groups.The percentage of the less than 80％ peak expiratory flow rate(PEF％) was significantly decreased in the vitamin D group(P=0.029).Conclusion Short-term low-dose vitamin D supplement can enhance the level of asthma control and has positive clinical application value.关键词
维生素D/儿童哮喘/控制水平/随机对照试验Key words
vitamin D/childhood asthma/control level/randomized controlled trial分类
医药卫生引用本文复制引用
陈江,任翼,何娜,石霖..维生素D3的补充对儿童哮喘控制的随机对照研究[J].重庆医学,2017,46(32):4505-4507,4510,4.基金项目
国家自然科学基金资助项目(30960411) （30960411）
海南省科技项目[(2012)36]. （2012）
