重庆医学2017，Vol.46Issue(33)：4613-4615,3.DOI:10.3969/j.issn.1671-8348.2017.33.002
PTGFR基因在DDH患儿关节囊和圆韧带中的表达变化及其与DDH发病的相关性研究
Expression change of PTGFR gene in articular capsule and ligamentum teres in DDH and its correlation with pathogenesis of DDH
摘要
Abstract
Objective To analyze the expression change of PTGFR gene in hip joint tissues of development dysplasia of the hip (DDH) and its correlation with DDH pathogenesis .Methods Eight age-and gender-matched children with DDH (DDH group) and control children (control group) were enrolled for conducting the compaison .The real-time quantitative PCR method and West-ern-blot method were adopted to detect the PTGFR mRNA and protein expression levels .Results PTGFR mRNA expression level in the hip articular capsule and ligamentum teres of the DDH group were significantly decreased compared with those of the control group (t=3 .472 ,2 .887 ,P<0 .05 ,) .The PTGFR protein expression level in the hip articular capsule and ligamentum teres of the DDH group were significantly decreased compared with those of the control group (t=5 .488 ,3 .942 ,P<0 .05) .Conclusion PTG-FR could play an important role in DDH pathogenesis and may be one of DDH pathogenic genes .关键词
关节囊/圆韧带/发育性髋关节发育不良/前列腺素F2α受体基因Key words
joint capsule/round ligament/developmental dysplasia of the hip/prostaglandin F2αreceptor gene分类
医药卫生引用本文复制引用
赵利华,焦勤,陈梦婕,王一臣,范玲燕,马峰,应灏,王隼..PTGFR基因在DDH患儿关节囊和圆韧带中的表达变化及其与DDH发病的相关性研究[J].重庆医学,2017,46(33):4613-4615,3.基金项目
国家自然科学基金项目(81401763) （81401763）
上海卫生计生委科研项目(20144Y0176) （20144Y0176）
上海市科学技术委员会科研项目(12DZ2295006) （12DZ2295006）
上海交通大学医学院"985"计划基金(YBKL2013008). （YBKL2013008）
