重庆医学2017，Vol.46Issue(33)：4622-4624,4627,4.DOI:10.3969/j.issn.1671-8348.2017.33.005
慢性乙型肝炎及乙型肝炎性肝硬化患者色氨酸代谢变化及其相关性分析
Tryptophan metabolism change in patients with chronic hepatitis B and hepatitis B cirrhosis and its correlation analysis
摘要
Abstract
Objective To investigate the tryptophan (Trp) metabolism change in the patients with chronic hepatitis B (CHB) and hepatitis B cirrhosis (HBC) and to analyze the related risk .Methods Eighty-one cases of CHB and 40 cases of HBC hospitalized in the First Affiliated Hospital of Chongqing Medical University from October 2015 to January 2016 served as the stud-y subjects ,and 40 healthy persons as the controls .High performance liquid chromatography -fluorescence detection (HPLC-FD) were adopted to detect the levels of plasma Trp ,kynurenine (Kyp) and its metabolite 5-hydroxy tryptamine (5-HT) .HBV-DNA vi-ral replication number was detected by real-time quantitative PCR .The serological indicators differences among 3 groups were ana-lyzed .The risk factors were analyzed and screened by the Logistic regression analysis and Pearson correlation analysis .Results Compared with the control group ,plasma 5-HT and Trp levels in the CHB group and HBC group were significantly decreased (P<0 .01);plasma Kyn/Trp in the HBC group was significantly higher than that in the other two groups (P<0 .01) .Kyn/Trp in the HBC group was negatively correlated with A/G (r= -0 .686 ,P<0 .01) ,and Kyn/Trp in the CHB group was positively correlated with Log DNA (r= 0 .784 ,P<0 .01) .The Logistic regression analysis indicated that Kyn/Trp was the risk factor of CHB and HBC .Conclusion Detecting plasma Trp and its metabolite can serve as the adjuvant indicators for assessing the progression of hep-atitis B .关键词
色氨酸/犬尿氨酸/5-羟色胺/乙型肝炎/乙型肝炎性肝硬化Key words
tryptophan/kynurenine/5-hydroxy tryptamine/chronic hepatitis B/hepatitis B cirrhosis分类
医药卫生引用本文复制引用
班艳娜,甄乾娜,邓琳琳,何一帆,丁敏..慢性乙型肝炎及乙型肝炎性肝硬化患者色氨酸代谢变化及其相关性分析[J].重庆医学,2017,46(33):4622-4624,4627,4.基金项目
国家自然科学基金资助项目(81200294). （81200294）
