重庆医学2017，Vol.46Issue(33)：4676-4679,4.DOI:10.3969/j.issn.1671-8348.2017.33.024
COX-2、MMP-9与PTEN在结肠腺癌组织中的表达及意义
Expression and significance of COX-2 ,MMP-9 and PTEN in colonic adenocarcinoma tissues
李志锋 1刘进忠 1石荣亚 1霍曼 1赵小利1
作者信息
- 1. 河北省保定市第一医院普外科 071000
- 折叠
摘要
Abstract
Objective To explore the expression and significance of COX-2 ,MMP-9 and PTEN in colonic adenocarcinoma tissues .Methods Seventy-two cases of pathologically archived paraffin specimens after colonic adenocarcinoma radical operation in the hospital from March 2014 to May 2016 were collected ,30 cases of colonic adenoma tissues and 30 cases of normal mucosal mem-brane tissues served as the controls .The expressions of COX-2 ,MMP-9 and PTEN were detected by adopting the immunohisto-chemical SP method .Then the correlation between COX-2 ,MMP-9 and PTEN with clinicopathological features of colonic adenocar-cinoma was analyzed .Results The positive expression rate of COX-2 and MMP-9 in colonic adenocarcinoma tissues was significant-ly higher than that in colonic adenoma tissues and normal colon mucosal membrane tissues (P<0 .05);the positive expression rate of PTEN was significantly lower than that in colonic adenoma tissues and normal colon mucosal membrane tissues (P<0 .05) .The expression of COX-2 ,MMP-9 and PTEN in colonic adenocarcinoma was correlated with the tumor invasive depth ,lymph node me-tastasis and TNM staging(P<0 .05) ,while had no correlation with sex ,age ,tumor morphology ,tumor size and differentiation de-gree(P>0 .05) .COX-2 ,MMP-9 and PTEN expressions showed negative correlation (r= -0 .260 ,-0 .282 ,P<0 .05) ,COX-2 and MMP-9 expression showed a positive correlation (r=0 .335 ,P=0 .004) .Conclusion The abnormal expression and interaction of COX-2 ,MMP-9 and PTEN are closely correlated with the occurrence ,invasion and metastasis of colonic adenocarcinoma .Their combined detection has an important significance for early diagnosis and prognosis assessment of colonic adenocarcinoma .关键词
基质金属蛋白酶-9/结肠腺癌/淋巴结转移/环氧合酶-2/PTENKey words
matrix metalloproteinase 9/colonic adenocarcinoma/lymph node metastasis/COX-2/PTEN分类
医药卫生引用本文复制引用
李志锋,刘进忠,石荣亚,霍曼,赵小利..COX-2、MMP-9与PTEN在结肠腺癌组织中的表达及意义[J].重庆医学,2017,46(33):4676-4679,4.
