摘要
Abstract
Objective To study the effect of PPI combined with FOLFOX regimen as postoperative adjuvant chemotherapy for stage Ⅱ and Ⅲ colorectal cancer.Methods 86 patients with colon cancer were recruited from January 2010 to January 2012 in our hospital and were randomly assigned to treatment group and control group,with 43 cases in each group.The treatment group was treated with PPI combined with FOLFOX regimen within 4 weeks after operation,and the control group with FOLFOX regimen.The expression of V-ATPase was measured by immunohistochemistry.The disease free survival (DFS) of followed up for 2 years,3 years,5 years and adverse events of chemotherapy were compared between two groups.Results The positive rates of V-ATPase in the treatment group and the control group were 67.44％ and 74.42％,respectively (P ＞ 0.05).The 2-year,3-year,and 5-year DFS rates were 76.74％,65.12％,55.81％,respectively,in treatment group and 58.14％,48.84％,39.53％ in control group,respectively (P ＞ 0.05).The 2-year DFS rate of stage Ⅲ colorectal cancer in the treatment group was 78.26％,which was higher than that in the control group (P ＜ 0.05).The 2-year and 3-year DFS rates of V-ATPase-positive patients in the treatment group were 75.86％ and 65.52％,respectively,which were significantly higher than those in the control group (P ＜ 0.05).There was no significant difference in DFS rate between the two groups in stage Ⅱ patients (P ＞ 0.05).Conclusion PPI combined with FOLFOX regimen can improve the DFS of patients with stage Ⅲ colorectal cancer and V-ATPases positive patients,with favorable long-term efficacy.关键词
结肠癌/辅助化疗/FOLFOX/质子泵抑制剂Key words
colon cancer/adjuvant chemotherapy/FOLFOX/proton pump inhibitor分类
医药卫生
