中国妇幼健康研究2017，Vol.28Issue(11)：1440-1442,3.DOI:10.3969/j.issn.1673-5293.2017.11.042
小儿呼吸系统感染病原菌的耐药性分析
Drug resistance of pathogens in childhood respiratory tract infection
高蕊 1王彦军 2杨亚荣1
作者信息
- 1. 西安市儿童医院感染科,陕西西安710003
- 2. 第四军医大学西京医院急诊科,陕西西安710032
- 折叠
摘要
Abstract
Objective To explore the drug resistance of pathogens causing respiratory tract infection in children so as to provide reference for the rational use of antimicrobial agents.Methods A total of 798 sputum samples from 256 children admitted in department of infectious diseases in Xi'an Children's Hospital were examined during January to December in 2016,and detection results were analyzed.Results Totally 265 strains of pathogens were isolated from 798 sputum samples with the detection rate of 33.21%,including 13 species(184 strains)of Gram-negative bacteria,4 species(32 strains)of Gram-positive bacteria,and 3 fungi(49 strains).There was significant difference in pathogens detection rate(χ2=235.374,P<0.05).The drug resistance of Pseudomonas aeruginosa to ampicillin and compound sulfamethoxazole was high,and that of Klebsiella pneumoniae and Escherichia coli to β-lactam antibiotics was high.The drug resistance of Haemophilus influenzae to β-lactam,compound sulfamethoxazole and second-generation cephalosporins was between 60% and 100%.Stenotrophomonas maltophilia was highly resistant to β-lactam, cefepime aminoglycosides and carbapenems.Staphylococcus aureus was not sensitive to β-lactam,erythromycin,compound sulfamethoxazole,levofloxacin and linofenam.Candida albicans was more sensitive to antimicrobial agents.Conclusion Bacterial pathogens in childhood respiratory tract infection show high resistance to commonly used β-lactam antibiotics.Clinical treatment should choose the experience medication,and the samples of patients are tested in a timely manner.Antibacterial agents are selected according to the pathogen spectrum and drug sensitive results.关键词
呼吸系统感染/病原菌/耐药性/小儿/抗生素Key words
respiratory tract infection/pathogens/drug resistance/children/antibiotics分类
医药卫生引用本文复制引用
高蕊,王彦军,杨亚荣..小儿呼吸系统感染病原菌的耐药性分析[J].中国妇幼健康研究,2017,28(11):1440-1442,3.
