广西医科大学学报2017，Vol.34Issue(11)：1578-1581,4.DOI:10.16190/j.cnki.45-1211/r.2017.11.11
G蛋白耦联受体30表达水平与子宫肌瘤发生的相关性研究
Correlation of G protein-coupled receptor 30 and uterine fibroid
黄晓燕 1李伟2
作者信息
- 1. 河池市人民医院妇产科,河池547400
- 2. 华中科技大学同济医学院附属同济医院妇产科,武汉430030
- 折叠
摘要
Abstract
Objective:To evaluate the correlation of G protein-coupled receptor 30 (GPR30) and uterine fibroid.Methods:30 patients with uterine fibroid treated in our hospital from Oct.2015 to may 2016 were selected.The mRNA and protein expression levels of GPR30 in the tissues of uterine fibroid and normal myometrium were determined by western blotting and RT-PCR,respectively.Results:The mRNA and protein expressions of GPR30 in uterine fibroid tissues were significantly up-regulated,and the GPR30 protein level was 3.9 times higher than that in normal myometrium tissues (P＜ 0.05).The patients with recurrent uterine fibroid had a significant increased in GPR30 mRNA and protein expression (P＜0.05),and the protein level of GPR30 was 1.6 times higher than those without relapse.When the largest diameter of the fibroid ＞≥5 cm,the GPR30 mRNA and protein expressions were significantly elevated (P＜0.05),and the protein level was 1.6 times higher than that of uterine fibroid with a diameter less than 5 cm.There was also significant difference in the mRNA and protein expression levels of GPR30 between solitary and multiple uterine leiomyomas (P＜0.05).Conclusion:GPR30 was closely related to the occurrence and progress of uterine fibroid.关键词
子宫肌瘤/G蛋白耦联受体30/雌激素Key words
uterine flesh/G protein-coupled receptor 30/estrogen分类
医药卫生引用本文复制引用
黄晓燕,李伟..G蛋白耦联受体30表达水平与子宫肌瘤发生的相关性研究[J].广西医科大学学报,2017,34(11):1578-1581,4.
