哈尔滨工程大学学报2017，Vol.38Issue(11)：1817-1822,6.DOI:10.11990/jheu.201703090
负载双抗癌药的双层微球设计及药物释放
Design of double-walled microspheres loaded with dual-anticancer drugs and associated drug release
摘要
Abstract
To study the coexistence of hydrophilic and hydrophobic anticancer drugs , this study describes the use of poly ( lactic-co-glycolic acid ) double-walled microspheres loaded with doxorubicin and curcumin employing the sol-vent evaporation method .Results show that the microspheres have a uniform particle size and good dispersibility . The introduction of dual biodegradable polymers reduces the initial burst and prolongs the total release time for doxorubicin and curcumin , which respectively reach 34 days and 39 days, and the microspheres degrade gradually within 21 days.This study can be used as a foundation for establishing a dual-drugs system .关键词
双层结构/微球/给药系统/聚乳酸-羟基乙酸共聚物/红外光谱/粒径/阿霉素/姜黄素Key words
double-walled structure/microspheres/drug delivery system/poly ( lactic-co-glycolic acid )/infrared spectroscopy/particle size/doxorubicin/curcumin分类
医药卫生引用本文复制引用
王晓丹,景晓燕,李茹民..负载双抗癌药的双层微球设计及药物释放[J].哈尔滨工程大学学报,2017,38(11):1817-1822,6.基金项目
国家国际科技合作项目(2015DFR50050). （2015DFR50050）
