郑州大学学报（医学版）2017，Vol.52Issue(6)：681-685,5.DOI:10.13705/j.issn.1671-6825.2017.06.005
新合成季铵盐单体化合物的体外抗菌和体内抗炎活性
Antibacterial activity in vitro and anti-inflammatory action in vivo of new quaternary ammonium salt monomer compounds
摘要
Abstract
Aim:To observe the activities of antibacterial in vitro and anti-inflammation in vivo of 4 kinds of synthe-sized quaternary ammonium salt monomer compounds .Methods:The liquid preparation and solid preparation at high , me-dium and low concentration of the four compounds were prepared , and their antibacterial activity against Staphylococcus au-rues, Escherichia coli and Salmonella were tested using the liquid preparations .The irritated effects were investigated on normal skin of rabbits.The common catheters smeared with the compounds were placed into the rabbit urethra for 5,10,15 d, then the plasma levels of IL-10 and TNF-αwere determined by ELISA , and the production of urethritis cells were inves-tigated by HE staining method on the 15th day.The rabbits with common catheter were the control .Results:Compound 2 and Compound 4 had better inhibitory effects on the three kinds of urethral flora (P<0.05), while Compound 1 and Com-pound 3 had no obvious inhibitory effect .Compound 2 and 4 had no irritated effect on the rabbit skin .The plasma level of IL-10 of Compound 2 and 4groups was higher, and that of TNF-αwas lower than the control group(P<0.05).The result of HE stainning showed that the number of inflammatory cells and the infiltration ability in Compound 2 and 4groups were lower than the control group .Conclusion:Compound 2 and Compound 4 may have good activities of antibacterial in vitro and anti-inflammation in vivo.关键词
季铵盐单体/抗菌活性/抗炎作用Key words
quaternary ammonium salt monomer/antibacterial activity/anti-inflammatory action分类
医药卫生引用本文复制引用
师莹莹,侯桂琴,赵琦,王洋,任彦丹,张梦影,鲁照明..新合成季铵盐单体化合物的体外抗菌和体内抗炎活性[J].郑州大学学报（医学版）,2017,52(6):681-685,5.基金项目
河南省科技攻关计划项目 132102210564 （）
