郑州大学学报（医学版）2017，Vol.52Issue(6)：694-697,4.DOI:10.13705/j.issn.1671-6825.2017.06.008
长期乙醇暴露对大鼠肺组织中TREM-1/2通路表达的影响
Effect of long-term alcohol exposure on TREM-1/2 pathway expression in rat lung tissue
摘要
Abstract
Aim:To investigate the effect of long-term alcohol exposure on the expressions of TREM-1,TREM-2 and DAP-12 in rat lung tissue .Methods:Forty SD rats were allocated into 2 groups randomly .The rats in alcohol group were lavagely given alcohol(volume fraction of 20%) at dose of 2.5 mL/(kg· d), and those in control group were given water . After four weeks , immunohistochemical staining and Western blot technique were used to detect the expressions of TREM -1,TREM-2 and DAP-12 in lung tissue.Results:After 4 weeks, the control rats had agile action , good appetite, no diar-rhea, and gained weight obviously .Compared with control group , the rats in alcohol group had no significant weight gain , and showed diarrhea symptoms , TREM-1 expression in rat lung tissue decreased , and TREM-2 and DAP-12 expressions in-creased(P<0.05).Conclusion: Long-term alcohol exposure may destroy the balance of TREM-1/2 pathway, thereby cause low immunity .关键词
肺/乙醇/TREM-1/TREM-2Key words
lung/alcohol/TREM-1/TREM-2分类
医药卫生引用本文复制引用
张伟宏,徐高磊,易诗琪,张译铮,沈建明,杨静尘,杨东斌..长期乙醇暴露对大鼠肺组织中TREM-1/2通路表达的影响[J].郑州大学学报（医学版）,2017,52(6):694-697,4.基金项目
国家自然科学基金资助项目 U1404814 （）
河南省高校科技创新人才支持计划 17HASTIT048 （）
