中医学报2017，Vol.32Issue(11)：2171-2175,2180,6.DOI:10.16368/j.issn.1674-8999.2017.11.566
黄芪-丹参药对活性成分网络药理学研究
Network Pharmacology Study on Major Active Components of Huangqi-Danshen Couplet Medicinals
摘要
Abstract
Objective:Molecular mechanism of major active components of Huangqi-Danshen couplet medicinals was analyzed by using network pharmacology method.And the correlations of multi components-multi targets-multi pathways were investigated.Method:Firstly,muhi components (astragaloside Ⅳ,ononin,formononetin,calycosin,isorhamnetin,salvianolic acid B,lithospermic acid,rosmarinic acid,danshensu,protocatechuic aldehyde,tanshinone ⅡA,dihydrotanshinone Ⅰ,tanshinone Ⅰ,cryptotanshinone)protein network of Huangqi-Danshen couplet medicinals was built on basis of PharmMapper database.Secondly,pathways of the proteins were obtained from MAS and KEGG databases.Finally,the components-targets-pathways network of Huangqi-Danshen couplet medicinals was built by Cytoscape software.Results:The results showed that 14 components of Huangqi-Danshen couplet medicinals involved 63 target proteins and 69 pathways.The results are validated by literature.In the network model,the average frequency of each target protein and each pathway was 8.31 and 7.62 times,respectively;and each compound was correlated with 4.57 proteins and 4.93 pathways.Conclusion:The results provided a reference for the further study of the pharmacodynamics and mechanism of Huangqi-Danshen couplet medicinals.关键词
黄芪/丹参/药对/网络分析/靶点预测Key words
Huangqi (Astragali Radix)/Danshen (Salviae Miltiorrhizae Radix et Rhizoma)/couplet medicinals/network analysis/target prediction分类
医药卫生引用本文复制引用
李伟霞,刘现磊,唐进法,孟祥乐,李学林..黄芪-丹参药对活性成分网络药理学研究[J].中医学报,2017,32(11):2171-2175,2180,6.基金项目
国家自然科学基金项目(U1504827) （U1504827）
