湖南中医药大学学报2017，Vol.37Issue(11)：1184-1187,4.DOI:10.3969/j.issn.1674-070X.2017.11.004
银莱汤对发热大鼠血清IL-1β、TNF-α、IL-6含量的影响
Effect of Yinlai Decoction on IL-1β, TNF-α, IL-6 Levels in Serum of Fever Rats
摘要
Abstract
Objective To explore the effect of Yinlai decoction on body temperature, Serum Content of IL-1β, TNF-α, IL-6 of Fever Rats. Methods 90 male rats were randomly divided into normal group, model group, aspirin group, and high, middle and low dose Yinlai decoction groups, 8 rats in each group. Fever rat models were induced with dorsal hypodermic injection of 20% dry yeast suspension, and they were fed with leechdom half an hour before building the fever model and 5 hours after building the fever model. The blood were taken at the 8th hour after building the model. The levels of IL-6, IL-1β and TNF-α in serum were detected by ELISA and RIA. Results Temperature in different doses of Yinlai decoction groups are lower than the model group (P<0.01). The IL-1β, TNF-α, IL-6 levels in serum were signifi-cantly lower than those in the model group (P<0.05). Conclusion Yinlai decoction shows obvious anti-febrile effect on fever rats. Its mechanism may relate to restraining the inflammation reaction and reducing the expression of IL-1β, TNF-α, IL-6 in serum.关键词
银莱汤/发热/炎症/IL-1β/TNF-α/IL-6Key words
Yinlai decoction/pyrexia/inflammation/IL-1β/TNF-α/IL-6分类
医药卫生引用本文复制引用
万宇翔,郑子安,白辰,王云辉,于河,刘铁钢,谷晓红..银莱汤对发热大鼠血清IL-1β、TNF-α、IL-6含量的影响[J].湖南中医药大学学报,2017,37(11):1184-1187,4.基金项目
国家自然科学基金项目(81403328) （81403328）
北京市教委产学研项目(1000062520040) （1000062520040）
北京中医药大学自主选题资助项目(2016-JYB-XS031). （2016-JYB-XS031）
