湖南中医药大学学报2017，Vol.37Issue(11)：1272-1276,5.DOI:10.3969/j.issn.1674-070X.2017.11.025
慢性阻塞性肺疾病急性加重患者痰病原菌分布及耐药性分析
Analysis of Distribution and Drug Resistance of Pathogens in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To analyze the distribution and drug resistance of pathogens in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), so as to guide the early clinical drug use better. Methods The clinical data of pathogens of 613 AECOPD patients who had received sputum culture examinations in the Department of Respiratory of our hospital from August 2014 to July 2016 were selected, and their distribution and drug resistance were analyzed. Results Totally, 406 strains of pathogenic bacteria were obtained, among which gram-negative bacteria, fungi, gram-positive bacteria were 247 (60.8%), 103 (25.4%) and 56 (13.8%) strains. The most common bacteria were Pseudomonas aeruginosa (17.0%), Candida albicans (12.8%), Staphylococcus aureus (9.9%), Acinetobacter baumannii/hemolytic (8.1%), Klebsiella pneumonia (7.9%), Escherichia coli (6.9%), Stenotrophomonas maltophilia (6.9%). The ratio of producing extended spectrum beta-lactamases (ESBLs) of Escherichia coli and Klebsiella pneumonia were 71.4% and 34.4%, respectively, and both of them had different re-sistance to many kinds of antibiotics. Pseudomonas aeruginosa, Acinetobacter baumannii/hemolytic, Stenotrophomonas maltophilia showed high resistance to many kinds of antibiotics. Conclusion Gram-negative bacteria was the main pathogenic bacteria for infection in AECOPD patients with high frequency of drug resistance, considering the local distribution and drug resistance of pathogens to select antibiotic was particularly important.关键词
慢性阻塞性肺疾病/急性加重/病原菌/耐药性Key words
chronic obstructive pulmonary disease/exacerbation/pathogenic bacteria/drug resistance分类
医药卫生引用本文复制引用
邹莹,李少杰,蒋勇前,黄兰花..慢性阻塞性肺疾病急性加重患者痰病原菌分布及耐药性分析[J].湖南中医药大学学报,2017,37(11):1272-1276,5.基金项目
珠海市卫生局医学科研项目(2013054). （2013054）
