中医药导报2017，Vol.23Issue(20)：57-58,61,3.
蒙药五根油剂对D-半乳糖致亚急性衰老模型小鼠的抗衰老作用研究
Study on Anti-aging Effect of Mongolian Medicine Wugen Youji （蒙药五根油剂）on Subacute Aging Model Mice Induced by D-galactose
摘要
Abstract
Objective:To study the anti-aging effect of Mongolian medicine Wugen Youji.Methods:The 60 Kunming mouse (half male and female) were randomly divided into 5 groups:normal group,model group,Mongolian medicine Wugen Youji low dose group and high dose group,vitamin E group.Except the normal control group,the other groups were subcutaneously injected with D-galactose,150 mg/(kg·d),to establish subacute aging model,and intragastric administration of Mongolian medicine Wugen Youji low dose group,high dose group and positive control group of vitamin E,dosage was 0.8 g/(kg·d),3.2 g/(kg·d),0.86 mg/(kg·d).Sacrificed after administration of 7 consecutive weeks,detect content change of superoxide dismutaseb (SOD),glutathione peroxidase (GSH-px) and malondialdehyde (MDA) in serum and brain tissues;changes of spleen and thymus index.Results:Mongolian medicine Wugen Youji each dose group can significantly improve the content of SOD and GSH-px,decreased MDA in serum and brain tissues;decreased the spleen index and thymus index,the effect of high dose group is better than the low dose group.Conclusion:Mongolian medicine Wugen Youji can significantly improve the antioxidant capacity of aging mouse,indicate that has anti-aging effect.关键词
蒙药五根油剂/D-半乳糖/抗衰老作用/小鼠Key words
Mongolian medicine Wugen Youji/D-galactose/anti-aging effect/mice分类
医药卫生引用本文复制引用
朝鲁,陈红梅,王秀兰,长春,靳文杰..蒙药五根油剂对D-半乳糖致亚急性衰老模型小鼠的抗衰老作用研究[J].中医药导报,2017,23(20):57-58,61,3.基金项目
内蒙古民族大学科学研究项目(NMDGY1440) （NMDGY1440）
内蒙古自治区研究生科研创新资助项目(B20151013601) （B20151013601）
内蒙古民族大学研究生创新项目(NMDBS1401) （NMDBS1401）
