四川大学学报（医学版）2017，Vol.48Issue(6)：905-910,6.
四川地区高敏肌钙蛋白T参考值的建立及其在胸痛患者中诊断急性心肌梗死的价值
Establishment of Reference Value of Hs-cTnT in Sichuan Region and Its Diagnostic Value in Patients with Chest Pain
摘要
Abstract
Objective To establish the reference value of high sensitive cardiac troponin T (hs-cTnT) and the efficiency of reference value in the diagnosis of chest pain.Methods Volunteers from eight independent communities in Chengdu,Sichuan were selected with detailed records of physical examination,electrocardiogram,ultrasound examination.The level of hs-cTnT for healthy volunteers was tested to determine ninety-ninth percentile references according to sex and ages.2 249 patients with chest pain in the emergency department of Western China Hospital from July 2009 to July 2014 were enrolled to measure the efficiency of reference value for diagnosing acute myocardial infarction (AMI).Results There were 1 305 volunteers included finally.Among them,the mean hs-cTnT level of male was 4.3 (3.2-5.9) ng/L,which was significantly higher than that of female 3.0 (3.0-3.1) ng/ L (P＜0.01).The correlation coefficient between age and hs-cTnT level was 0.43 (male) and 0.29 (female),and the P-value was less than 0.01.The 99th percentile values of male were 10.8 ng/L,15.4 ng/L and 19.7 ng/Lfor ＜45 yr.,45-＜ 60 yr.and ≥ 60 yr.,respectively.Those values of female were 4.6 ng/L,8.9 ng/L,18.8 ng/L,respectively.There was no difference in sensitivity and specificity between the value we figured out and manufactures provided (14.0 ng/L) for those ＜60 yr..For the patients ≥60 yr.,the sensitivity and negative predictive value did not show diversity (P＞0.05) but the specificity and positive predictive value showed significant difference (male:0.67 vs.0.56 and 0.83 vs.0.79,P＜0.05;female:0.75 vs.0.68 and 0.74 vs.0.69,P＜0.05).Conclusion We recommends that the ninety-ninth percentile reference value of patients ＜ 60 yr.should be 14.0 ng/L,while 20.0 ng/L for those patients≥60 yr..关键词
急性心肌梗死/高敏肌钙蛋白T/第99百分位参考值/胸痛Key words
Acute myocardial infarction/High sensitive cardiac troponin T/Ninety-ninth percentile reference value/Chest pain引用本文复制引用
郭英,都向阳,黄华兰,王伟青,聂鑫,李贵星..四川地区高敏肌钙蛋白T参考值的建立及其在胸痛患者中诊断急性心肌梗死的价值[J].四川大学学报（医学版）,2017,48(6):905-910,6.基金项目
四川省科技支撑项目(No.2016SZ0044)资助 （No.2016SZ0044）
