四川中医2017，Vol.35Issue(11)：105-108,4.
经方葛根芩连汤对湿热型糖尿病的口腔微生物学的研究
Effect of Gegen Qinlian Decoction on Tongue Microbiota of Type 2Diabetes Patients with Dampness-heat Syndrome
摘要
Abstract
Objective:To study the effect of Gegen Qinlian Decoction on tongue microbiota of type 2diabetes patients with dampness-heat syndrome.Methods:120cases type 2diabetes patients with dampness-heat syndrome in our hospital from 2015October to 2017March were chose,and were divided into experiment group (60cases) and controlled group (60cases).The experiment group was treated with Gegen Qinlian Decoction combined with routine hypoglycemic agents.The controlled group was treated with routine hypoglycemic agents.The effect of Gegen Qinlian Decoction on tongue microbiota was tested in the two groups.Results:The total TCM symptom grade effective rate in the experiment group was obviously higher than that in the controlledgroup (91.67％ ＞76.67％) (P＜0.05).The total biochemical indicator of west medicine in the experiment group was obviously than the controlled group (86.87％ ＞63.33％) (P＜0.05).The positive rate of Streptococcus in the experiment group (13.21 ± 1.01) was obviously lower than the controlled group (33.21 ± 1.31) (P＜0.05).The positive rate of Fusobacterium in the experiment group (32.21±2.01) was obviously higher than the controlled group (12.21± 1.01) (P＜0.05).Spearman results showed that,in the experiment group,there were positive correlations between Fusobacterium and the reduction rate of dampness-heat syndrome (r=0.421,P=0.003).However,there were negative correlations between Streptococcus and the reduction rate of dampness-heat syndrome (r=-0.430,P=0.002).The same there were positive correlations between Fusobacterium and the reduction level of blood sugar (r =0.513,P =0.004).However,there were negative correlations between Streptococcus and the reduction level of blood sugar (r=-0.612,P=0.021).Conclusion:Using Gegen Qinlian Decoction combined with Mefformin in the treatment of type 2diabetes patients with dampness-heat syndrome has good curative effect.The levels of Fusobacterium and Streptococcusare can be regarded with the relevant indexes in type 2diabetes patients with dampness-heat syndrome.关键词
葛根芩连汤/湿热证/糖尿病/口腔微生物学Key words
Gegen Qinlian Decoction/Dampness-heat syndrome/Type 2diabetes/Tongue microbiota分类
医药卫生引用本文复制引用
郭亚芳,陆红,曾艺鹏,马俐,顾勇刚,顾文忠..经方葛根芩连汤对湿热型糖尿病的口腔微生物学的研究[J].四川中医,2017,35(11):105-108,4.基金项目
上海市普东新区名中医继承培养项目(编号:PD2YXK-6-2014027) （编号:PD2YXK-6-2014027）
上海市基层名老中医专家传承研究工作室建设项目(编号:JCZYGZS-001) . （编号:JCZYGZS-001）
