中国组织工程研究2017，Vol.21Issue(33)：5407-5412,6.DOI:10.3969/j.issn.2095-4344.2017.33.025
人脐带间充质干细胞不同移植途径治疗缺血性脑损伤以及生物发光技术示踪的研究及进展
Human umbilical cord mesenchymal stem cell transplantation by different pathways and stem cell tracing by bioluminescence imaging in the treatment of ischemic brain injury
摘要
Abstract
BACKGROUND: Transplantation of human umbilical cord mesenchymal stem cells can effectively promote the recovery of neurological function in animal models of ischemic brain injury. However, it is unclear on the mechanisms underlying the therapeutic actions of human umbilical cord mesenchymal stem cells and the optimal transplantation way. Bioluminescence imaging has been widely used in the field of stem cell transplantation for real-time dynamic monitoring of the proliferation, migration and survival of transplanted stem cells. OBJECTIVE: To review the studies of human umbilical cord mesenchymal stem cells in the treatment of ischemic brain injury and the recent research progress of bioluminescence imaging in the stem cell transplantation for the treatment of ischemic brain injury. METHODS: The key words were "human umbilical cord mesenchymal stem cells, brain ischemia, bioluminescence imaging" in English and Chinese, respectively. The first author retrieved PubMed database, Chinese Journal Full-text Database for relevant articles published from January 2011 to December 2016. Literatures with repetitive content and poor relationship were excluded. A total of 98 literatures were initially retrieved, and finally 38 articles met the inclusion criteria. RESULTS AND CONCLUSION: Human umbilical cord mesenchymal stem cells can be transplanted via the vein, artery, lumbar puncture, stereotactic operation, intraventricular approach in the treatment of ischemic brain injury. They have their own merits and demerits, which mainly focus on stem cell migration range, survival rate, safety and so on. It has been found that bioluminescence imaging technology for the living is characterized by real-time dynamic monitoring, high sensitivity, high-time resolution and easy operation, which can be used to monitor the migration, proliferation and survival of transplanted stem cells in vivo. Therefore, further investigation on the mechanism of human umbilical cord mesenchymal stem cells that are labeled by bioluminescence imaging technology and selection of the optimal transplantation approach is warranted.关键词
干细胞/移植/人脐带间充质干细胞/移植途径/缺血性脑损伤/生物发光成像技术/国家自然科学基金分类
医药卫生引用本文复制引用
王立新,李惠平..人脐带间充质干细胞不同移植途径治疗缺血性脑损伤以及生物发光技术示踪的研究及进展[J].中国组织工程研究,2017,21(33):5407-5412,6.基金项目
国家自然科学基金面上项目(81373569) the National Natural Science Foundation of China, No. 81373569 （81373569）
