西南国防医药2017，Vol.27Issue(11)：1150-1153,4.DOI:10.3969/j.issn.1004-0188.2017.11.003
氢吗啡酮在纤维支气管镜BAL治疗VAP的应用
Application of hydromorphone in treatment of VAP with bronchoscopic BAL
师华华 1王健 1刘天瑜 1刘彩云2
作者信息
- 1. 051430河北栾城,栾城人民医院重症医学科
- 2. 051430河北栾城,栾城人民医院支气管镜室
- 折叠
摘要
Abstract
Objective To explore the application value of hydromorphone sedation in the treatment of ventilator-associated pneumonia (VAP) with bronchoscopic bronchial alveolar lavage (BAL).Methods A total of 60 patients with VAP were selected and randomly divided into group A (n =28) and group B (n=32).The two groups received indolent BAL treatment with propofol and hydromorphone respectively.The vital signs at different times,the changes in respiratory mechanical indexes,the sedation scores in the process of lavage and the adverse reactions between the two groups were compared.Results The heart rate (HR) and breathing rate (BR) during and 10 min after the operation were much lower than those before the operation(P ＜ 0.05),but the changes in group B were significantly minor in comparison with those in group A (P ＜ 0.05).The peak inspiratory pressure (PIP),work of breathing (WOB) and resistance in airways (RAW) 60 min and 120 min after lavage in group A were significantly lower than those before lavage (P ＜ 0.05),lung dynamic compliance (CD) was much higher than that before lavage(P ＜ 0.05);the PIP and RAW 60 min after lavage in group B were much lower than those before lavage (P ＜ 0.05),but CD was significantly higher than that before lavage(P ＜ 0.05);the PIP and WOB 120 min after lavage in group B were much lower than those before lavage (P ＜ 0.05),but CD was significantly higher than that before lavage (P ＜ 0.05);the changes in the PIP,WOB,CD and RAW in group B were minor in comparison with those in group A (P ＜ 0.05);the sedation scores in the process of lavage and adverse reactions showed no statistical difference between the two groups (P ＞ 0.05).Conclusion The application of hydromorphone sedation in the treatment of VAP with BAL can reduce body stress state and the impacts on breathing function.关键词
氢吗啡酮/支气管肺泡灌洗/呼吸机相关性肺炎/镇静/呼吸力学指标Key words
hydromorphone/BAL/VAP/sedation/respiratory mechanical index分类
医药卫生引用本文复制引用
师华华,王健,刘天瑜,刘彩云..氢吗啡酮在纤维支气管镜BAL治疗VAP的应用[J].西南国防医药,2017,27(11):1150-1153,4.
