摘要
Abstract
Objective To study the impacts of three-step sequential therapy on induced sputum and bronchoalveolar lavage fluid (BALF) related indicators in senile patients with elderly steroid-dependent asthma (SDA).Methods A total of 58 senile patients (≥65years old) with SDA were selected and randomly divided into a control group and a treatment group (n=29,respectively).The control group was treated with budesonide inhalation therapy and the treatment group with three-step sequential therapy until two weeks after the complete withdrawal of hormone.The lung function and changes in induced sputum and BALF related indicators between the two groups were compared.Results After the treatment,the forced vital capacity (FVC),the second-1 forced expiratory volume (FEV1),the percentage of the second-1 force expiratory volume in the expected value (FEV1pre) and the FEV1/FVC in the two groups increased significantly,and the increase in the treatment group was greater than that in the control group (P ＜ 0.05);the contents of induced sputum and the lymphocytes,neutrophils,eosinophils and eosinophils of BALF and interleukin-5 (IL-5) in the two groups decreased greatly,the content of macrophage increased dramatically,and the decrease or increase in the treatment group was greater than that in the control group (P ＜ 0.05).During the treatment,no adverse reactions occurred in the two groups.Conclusion Three step sequential therapy can significantly improve the lung function of senile patients with DSA,lower the degree of inflammatory reaction,has better effects than simple budesonide inhalation therapy,and has no significant adverse reactions.关键词
激素依赖性哮喘/三步序贯法/老年/肺功能Key words
SDA/three-step sequential therapy/senile patient/lung function分类
医药卫生
