西南国防医药2017，Vol.27Issue(11)：1162-1165,4.DOI:10.3969/j.issn.1004-0188.2017.11.007
PEW对血液透析患者CVD危险因素水平的影响
Impacts of PEW on levels of CVD risk factors in hemodialysis patients
王铁锁 1刘华 2李冬梅 1王莹3
作者信息
- 1. 713800陕西三原,三原县医院肾内科血液净化室
- 2. 西安交通大学第一附属医院血液净化科
- 3. 713800陕西三原,三原县医院内分泌科
- 折叠
摘要
Abstract
Objective To explore the impacts of protein-energy wasting (PEW) on the levels of cardiovascular disease (CVD) risk factors in hemodialysis patients.Methods A batch of 33 patients with end-stage renal disease to receive PEW maintenance hemodialysis in our hospital were selected to constitute an observation group,and another 33 patients to receive non-PEW maintenance hemodialysis in our hospital in the corresponding period were selected to constitute a control group.The levels of CVD risk factors between the two groups were compared.Results The concentrations of high-sensitivity C-reactive protein (hs-CRP) and soluble intercellular adhesion molecule-1 (sICAM-1) in the observation group were significantly higher than those in the control group (P ＜ 0.05);the concentrations of soluble vascular cell adhesion molecule-1 (sVCAM-1),sE-selectin,endothelin-1 (ET-1),lipoprotein (a)[Lp(a)],malondialdehyde (MDA) and nitric oxide (NO) showed no significant difference between the two groups(P ＞ 0.05);theconcentrations of serum sICAM-1,sVCAM-1,sE-selectin and MDA in patients with microinflammatory reactions were much higher thanthose in the patients without microinflammatory reactions(P ＜ 0.05);the concentrations of ET-1,Lp(a) and NO showed no significantdifference between the two groups(P ＞ 0.05).Conclusion PEW can cause the increase of the levels of CVD risk factors hs-CRP and sICAM-1 in hemodialysis patients and may increase the risk of CVD.关键词
蛋白质能量消耗/血液透析/心血管疾病/危险因素Key words
PEW/hemodialysis/CVD/risk factor分类
医药卫生引用本文复制引用
王铁锁,刘华,李冬梅,王莹..PEW对血液透析患者CVD危险因素水平的影响[J].西南国防医药,2017,27(11):1162-1165,4.
