摘要
Abstract
Objective To explore the clinical value of drainage fluid soluble medullary cell trigger receptor-1(sTREM-1) in early prediction of secondary sepsis of multiple abdominal injuries.Methods A total of 175 patients with multiple abdominal injuries admitted to our hospital were selected as study subjects and divided into a sepsis group (n=114) and a control group (n=61) according to whether secondary sepsis occurred in the process of treatment.The drainage fluid and serum sTREM-1,c-reactive protein (CRP),procalcitonin (PCT) and other indexes of all patients were detected within 24 hours upon the admission.The detection results between the two groups were compared.Results (1)The levels of drainage fluid and serum sTREM-1 in the sepsis group were significantly higher than those in the control group(P ＜ 0.05);the serum CRP and PCT showed no statistical difference between the two groups (P ＞ 0.05).(2)The sensitivity,specificity,cut-off,area under curve (A UC) of ROC and A UC 95％CI of secondary sepsis were diagnosed and predicted by means of drainage fluid sTREM-1 and were 78.24％,83.57％,77.91 ug/L,0.85 (closest to 1.0) and 0.795-0.917,respectively.The analysis of ROC curve showed that the AUC of the ROC of secondary sepsis of multiple abdominal injuries diagnosed by means of drainage fluid sTREM-1 was much greater than that of serum sTREM-1,CRP and PCT and the difference had statistical significance (P ＜ 0.05).The analysis also showed that drainage fluid sTREM-1 had the most significant effects in the prediction of secondary abdominal sepsis.Conclusion Both drainage fluid and serum sTREM-1 can be used for the early prediction of secondary sepsis of multiple abdominal injuries,but the clinical predictive value of drainage fluid sTREM-1 is higher.关键词
可溶性髓系细胞触发受体-1/腹部/多发伤/脓毒症/早期预测Key words
sTREM-1/multiple abdominal injuries/sepsis/early prediction分类
医药卫生
