中国比较医学杂志2017，Vol.27Issue(11)：1-5,5.DOI:10.3969.j.issn.1671-7856.2017.11.001
恒古骨伤愈合剂对骨折树鼩血液生理和脏器系数的影响
Effect of Osteoking on blood physiological parameters and organ indexes in female tree shrews with osteoporotic fracture
摘要
Abstract
Objective To evaluate the effect of Osteoking on blood physiological parameters and organ indexes in the ovariectomized tree shrew model of osteoporotic fracture(OPF). Methods A total of 30 4-month-old female tree shrews(Tupaia belangeri)were randomly divided into control group, model group and treatment group, with 10 in each group. Bilateral ovaries of the tree shrews in the treatment group and model group were removed and osteoporosis was confirmed 6 months later. Then tibial fractures were generated. From the next day of fracture,tree shrews in the treatment group were gavaged with Osteoking once every two days,and tree shrews in the model group and control group were gavaged with equal volume of sterile saline. After gavaging for 3 months,16 blood physiological parameters and 6 organ indexes of the tree shrews in each group were measured. Results Among all of the 16 blood physiological parameters,the number of white blood cells,the absolute value and percentage of lymphocytes(P < 0.01)and monocytes(P < 0.05)in the model group were significantly lower than those in the control group after 3 months. Compared with the model group, the absolute value and percentage of monocytes(P < 0.01)and lymphocytes,the number of white blood cells(P < 0.05) and the spleen coefficient were significantly increased(P < 0.05)in the treatment group. Conclusions Osteoking can improve the immunity of tree shrews with osteoporotic fracture.关键词
双侧去卵巢/骨质疏松性骨折/树鼩/免疫力/恒古骨伤愈合剂Key words
Bilateral ovariectomy/Osteoporotic fracture/Tree shrews/Immunity/Osteoking分类
医药卫生引用本文复制引用
吴超,唐薇,赵宏斌,李进涛,角建林,袁鑫,郑红..恒古骨伤愈合剂对骨折树鼩血液生理和脏器系数的影响[J].中国比较医学杂志,2017,27(11):1-5,5.基金项目
国家自然科学基金项目(编号:81460647) （编号:81460647）
云南省应用基础研究计划项目[编号:2014FB033,2017FE468(-014 （）
016)]. （）
