中国比较医学杂志2017，Vol.27Issue(11)：100-105,6.DOI:10.3969.j.issn.1671-7856.2017.11.021
异质性胞核核糖核蛋白K与肿瘤研究的最新进展
Recent progress in research of heterogeneous nuclear ribonucleoprotein K related with tumor pathogenesis and progression
摘要
Abstract
Over the past few decades, the classification of oncogenes or tumor suppressor genes has been an important topic in cancer biology. However,it is difficult to classify some genes. Heterogeneous nuclear ribonucleoprotein K(HNRNPK)is a nucleic acid-binding protein,which is involved in the regulation of gene expression,signal transduction and many other cellular processes. In recent years, it has been found that HNRNPK is overexpressed in many types of tumors,and its overexpression is negatively correlated with the prognosis of patients,suggesting that HNRNPK may play a role as an oncogene in tumorigenesis. In contrast,however,HNRNPK has also been considered as a tumor suppressor gene in acute myeloid leukemia(AML). Therefore, in this article we summarize and discuss the recent progress in the molecular functions and regulatory mechanisms of HNRNPK in tumorigenesis and progression.关键词
异质性胞核核糖核蛋白K/肿瘤/分子功能Key words
Heterogeneous nuclear ribonucleoprotein K/HNRNPK/Tumors/Molecular functions分类
医药卫生引用本文复制引用
黄昊,杨星九,李梦媛,朱瑞敏,高苒..异质性胞核核糖核蛋白K与肿瘤研究的最新进展[J].中国比较医学杂志,2017,27(11):100-105,6.基金项目
协和青年科研基金(编号:3332016078) （编号:3332016078）
中央级公益性科研院所基本业务费(编号:2016RC310012). （编号:2016RC310012）
