中国现代医学杂志2017，Vol.27Issue(28)：16-21,6.DOI:10.3969/j.issn.1005-8982.2017.28.004
冷沉淀外敷对家兔感染创面修复的影响
Plama cryoprecipitate for repair of infected wounds in rabbits
摘要
Abstract
Objective To observe the effect of plasma cryoprecipitate on the repair of rabbit infective wounds, and then explore the mechanism of the cryoprecipitate in promoting the healing of rabbit infective wounds. Methods Twelve healthy adult rabbits, according to the improved Fu Xiaobing full-thickness skin defect method, were made into wound infectious animal surface ulcer model, and then were treated respectively with the cryoprecipitate, Kangfuxin solution, MEBO or Vaseline gauze dressing. On the 3rd, 7th, 12th and 17th day of treatment, the microvascular density (MVD), healing rate, new epithelial coverage rate and TGF-β1 expression of the wound were tested. Results On the 3rd day of treatment, MVD rose in all the groups; on the 3rd and 7 th day, MVD in the cryoprecipitate group was statistically different from that of the rest three groups (χ23d = 15.151, χ27d = 27.837;P = 0.002 and 0.000); after the 12th day, new blood vessels gradually reduced. The wound healing rate and the new epithelial coverage rate in the cryoprecipitate group were higher than those in the Kangfuxin solution group and the Vaseline group (P < 0.05). The wound healing time in the cryoprecipitate group was significantly shorter than that in the other groups (H = 11.169, P = 0.011). TGF-β1 expression in the cryoprecipitate group was higher than that in the other three groups (χ23d = 17.400, χ27d = 21.969; P = 0.001 and 0.000), and maintained high level during the entire repair process. Conclusions The cryoprecipitate can increase MVD of the wound, promote the new epithelial coverage, and accelerate wound healing through up-regulation of TGF-β1 expression in the wounds.关键词
冷沉淀/创面愈合/微血管密度/转化生长因子β1Key words
cryoprecipitate/wound repair/microvascular density/TGF-β1分类
医药卫生引用本文复制引用
胡捷,刘庚勋,江小工,胡嘉玮,钟霞,董勇云,朱燕..冷沉淀外敷对家兔感染创面修复的影响[J].中国现代医学杂志,2017,27(28):16-21,6.基金项目
湖南省教育厅项目(No:14C0711) （No:14C0711）
