中国现代医学杂志2017，Vol.27Issue(28)：36-40,5.DOI:10.3969/j.issn.1005-8982.2017.28.007
SRPX2在胃癌中的表达及对细胞侵袭的影响
Expression of SRPX2 in human gastric carcinoma and its role in cell invasion
李婷 1彭波1
作者信息
- 1. 武汉大学附属同仁医院(武汉市第三医院)消化内科,湖北 武汉 430070
- 折叠
摘要
Abstract
Objective To detect the expression of Sushi Repeat Containing protein X Linked 2 (SRpX2) in human gastric carcinoma (GC) and its role in cell invasion. Methods qRT-pCR and immunohistochemistry were applied to detect the expression of SRpX2 in GC (n = 45) and matched tumor-adjacent tissues. The correlations between SRpX2 expression and clinical features were analyzed by pearson chi-square test. siRNA was used to silence the expression of SRpX2 in MGC-803 cells. The effect of SRpX2 on cell invasion was measured by transwell assay. MMp-2 expression was detected after silencing SRpX2 expression. Results The expression of SRpX2 was significantly up-regulated in the GC tissues, and the high expression of SRpX2 was associated with the lymphatic metastasis and advanced TNM stages (stage Ⅲ and Ⅳ ) (P < 0.05). Silencing SRpX2 could inhibit cell invasion and MMp-2 expression in the MGC-803 cells. Conclusions The expression of SRpX2 is significantly higher in GC tissues, which is correlated to tumor metastases. Silencing SRpX2 could achieve an anti-cancer role through inhibition of cell invasion.关键词
含sushi重复蛋白X连锁2/胃癌/表达/侵袭Key words
Sushi Repeat Containing protein X Linked 2/gastric carcinoma/expression/invasion分类
医药卫生引用本文复制引用
李婷,彭波..SRPX2在胃癌中的表达及对细胞侵袭的影响[J].中国现代医学杂志,2017,27(28):36-40,5.
