中国现代医学杂志2017，Vol.27Issue(28)：56-60,5.DOI:10.3969/j.issn.1005-8982.2017.28.011
术中分层冷冻切片在乳腺癌前哨淋巴结活检中的诊断价值
Diagnostic value of intraoperative frozen section in sentinel lymph node biopsy of breast cancer
摘要
Abstract
Objective To investigate the clinical value of method of detecting sentinel lymph node (SLN) by different frozen sections in the surgical treatment of breast cancer. Methods Sixty-seven breast cancer patients were given methylene blue and successfully underwent sentinel lymph node biopsy. Intraoperative frozen sections of SLN were made and hE staining was performed. The pathological results of single slice, 3 slice and 6 slice were recorded. postoperative routine hE staining of SLN paraffin sections was performed and considered as the standard of the diagnosis of SLN metastasis. Results of pathological diagnosis of different frozen sections were compared with the results of paraffin sections. Results The routine paraffin section results of the 67 patients revealed positive SLN in 19 cases, false negative SLN in 3 cases, the false negative rate was 13.6% (3/22). Comparison of the results of different slicing methods of frozen sections with paraffin sections of SLN showed the sensitivity of single slice was 21.1% (4/19), the coincidence rate was 73.1% (49/67), the specificity was 100% (45/45); the sensitivity of 3 slice was 31.6% (6/19), the coincidence rate was 76.1% (51/67), the specificity was 97.8% (44/45); the sensitivity of 6 slice was 84.2% (16/19), the coincidence rate was 91.1% (61/67), the specificity was 95.6% (43/45). The sensitivity and coincidence rates of the 6 slice were significantly higher than those of 3 slice and single slice, the differences were significant (P < 0.05). The difference between the single slice group and the 3 slice group were not significant (P > 0.05). Conclusions SLN intraoperative frozen pathological diagnosis is a reliable and fast method for diagnosis of SLN metastais. Multilayer section method can improve the detection rate of SLN metastasis, the results of 6 layer frozen section is close to postoperative pathological results of paraffin section.关键词
乳腺肿瘤/前哨淋巴结/冷冻切片/病理诊断Key words
breast cancer/sentinel lymph node/frozen section/pathological examination分类
医药卫生引用本文复制引用
黄自明,王蓉,郑媛,卢文亮,陈波,魏刚,高丹,薛明兴,叶春梅..术中分层冷冻切片在乳腺癌前哨淋巴结活检中的诊断价值[J].中国现代医学杂志,2017,27(28):56-60,5.基金项目
湖北省自然科学基金(No:2013CFB047) （No:2013CFB047）
