中国现代医学杂志2017，Vol.27Issue(28)：66-69,4.DOI:10.3969/j.issn.1005-8982.2017.28.013
同型半胱氨酸和超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性分析
Correlations of homocysteine and hypersensitive c-reactive protein with coronary heart disease
张秋焕 1辛成德 2钟白云1
作者信息
- 1. 中南大学湘雅医院 检验科,湖南 长沙 410008
- 2. 中南大学湘雅医学院医学检验系,湖南 长沙 410013
- 折叠
摘要
Abstract
Objective To investigate the correlations of serum homocysteine (hcy) and hypersensitive C-reactive protein (hs-CRp) levels with coronary heart disease and analyze their clinical significance for diagnosis and staging of coronary heart disease. Methods Circulating enzymatic assay and latex turbidimetric method were respectively used to determine the levels of serum hcy and hs-CRp in 110 patients with coronary heart disease. There were 35 cases in stable angina pectoris (SAp) group, 32 cases in unstable angina pectoris (UAp) group and 43 cases in acute myocardial infarction (AMI) group; meanwhile 30 healthy cases having physical examinations were taken into control group. Results The hcy and hs-CRp levels in each subgroup of coronary heart disease were statistically different from those in the control group (P < 0.05). In comparison of the level of hcy among various subgroups of coronary heart disease, AMI group >UAp group >SAp group, the differences were statistically significant (P < 0.05). The level of hs-CRp in the AMI group was statistically different from that in the UAp group and the SAp group (P < 0.05), while there was no statistically significant difference between the UAp group and the SAp group (P > 0.05). The level of hcy and hs-CRp had no correlation in the SAp group and the UAp group (r = 0.263 and 0.311, P > 0.05). The level of serum hcy and hs-CRp had positive correlation in the AMI group (r = 0.559, P < 0.05). Conclusions hcy and hs-CRp are closely related to the occurrence of coronary heart disease. Elevated serum hcy and hs-CRp levels are good indicators for the severity of coronary artery lesions, which play very important roles in predicting the risk, diagnosis, staging and prognosis assessment of coronary heart disease.关键词
同型半胱氨酸/超敏C反应蛋白/冠状动脉粥样硬化性心脏病(冠心病)Key words
homocysteine/hypersensitive C-reactive protein/coronary heart disease分类
医药卫生引用本文复制引用
张秋焕,辛成德,钟白云..同型半胱氨酸和超敏C反应蛋白与冠状动脉粥样硬化性心脏病的相关性分析[J].中国现代医学杂志,2017,27(28):66-69,4.
